Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin

Balmiki Ray, Debomoy K. Lahiri

Research output: Contribution to journalReview article

121 Scopus citations

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. Deposition of amyloid β plaque and associated neuroinflammation are the major hallmarks of AD. Whereas reactive oxygen species (ROS) and activated microglial cells contribute to neuronal loss, nuclear factor κB and apolipoprotein E participate in inflammatory process of AD. Current FDA approved drugs provide only symptomatic relief in AD. For broad spectrum of activity, some natural products are also being tested. Turmeric is used as an anti-inflammatory medicine in various regions of Asia. Curcumin, which is a yellow colored polyphenol compound present in turmeric, showed anti-inflammatory properties. Herein, we discuss the neurobiological and neuroinflammatory pathways of AD, evaluate different molecular targets and potential therapeutic agents, including curcumin, for the treatment of AD.

Original languageEnglish (US)
Pages (from-to)434-444
Number of pages11
JournalCurrent Opinion in Pharmacology
Volume9
Issue number4
DOIs
StatePublished - Aug 1 2009

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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