Neurologic complications of pediatric liver transplantation

Bhuwan P. Garg, Laurence E. Walsh, Mark D. Pescovitz, Hema Patel, Sonny Chong, Ronald S. Filo, Joseph Fitzgerald

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The neurologic complications of 24 children, ages 5 months to 18 years, following orthotopic liver transplantation at the Indiana University hospitals are reported. Biliary atresia (14 patients) was the most common cause for orthotopic liver transplantation. Three children died. Seventeen children (70%) had no neurologic deficit on follow-up 6 months or longer after transplantation. Eleven children (46%), including 4 of 16 patients (25%) who had received OKT3, had neurologic complications. Seven children (29%) had newonset seizures; 4 of these patients had status epilepticus. Two children had intracranial hemorrhage. Seizures occurred later in children than in adults following orthotopic liver transplantation and were not associated with poor prognosis. Longer term follow-up is indicated to assess subtle, cognitive deficits following liver transplantation in children.

Original languageEnglish (US)
Pages (from-to)444-448
Number of pages5
JournalPediatric Neurology
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1993

Fingerprint

Liver Transplantation
Nervous System
Pediatrics
Seizures
Biliary Atresia
Muromonab-CD3
Status Epilepticus
Intracranial Hemorrhages
Neurologic Manifestations
Transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Garg, B. P., Walsh, L. E., Pescovitz, M. D., Patel, H., Chong, S., Filo, R. S., & Fitzgerald, J. (1993). Neurologic complications of pediatric liver transplantation. Pediatric Neurology, 9(6), 444-448. https://doi.org/10.1016/0887-8994(93)90023-6

Neurologic complications of pediatric liver transplantation. / Garg, Bhuwan P.; Walsh, Laurence E.; Pescovitz, Mark D.; Patel, Hema; Chong, Sonny; Filo, Ronald S.; Fitzgerald, Joseph.

In: Pediatric Neurology, Vol. 9, No. 6, 01.01.1993, p. 444-448.

Research output: Contribution to journalArticle

Garg, BP, Walsh, LE, Pescovitz, MD, Patel, H, Chong, S, Filo, RS & Fitzgerald, J 1993, 'Neurologic complications of pediatric liver transplantation', Pediatric Neurology, vol. 9, no. 6, pp. 444-448. https://doi.org/10.1016/0887-8994(93)90023-6
Garg, Bhuwan P. ; Walsh, Laurence E. ; Pescovitz, Mark D. ; Patel, Hema ; Chong, Sonny ; Filo, Ronald S. ; Fitzgerald, Joseph. / Neurologic complications of pediatric liver transplantation. In: Pediatric Neurology. 1993 ; Vol. 9, No. 6. pp. 444-448.
@article{c7d9e7cc11d344dbb639d4d6b9e28ecf,
title = "Neurologic complications of pediatric liver transplantation",
abstract = "The neurologic complications of 24 children, ages 5 months to 18 years, following orthotopic liver transplantation at the Indiana University hospitals are reported. Biliary atresia (14 patients) was the most common cause for orthotopic liver transplantation. Three children died. Seventeen children (70{\%}) had no neurologic deficit on follow-up 6 months or longer after transplantation. Eleven children (46{\%}), including 4 of 16 patients (25{\%}) who had received OKT3, had neurologic complications. Seven children (29{\%}) had newonset seizures; 4 of these patients had status epilepticus. Two children had intracranial hemorrhage. Seizures occurred later in children than in adults following orthotopic liver transplantation and were not associated with poor prognosis. Longer term follow-up is indicated to assess subtle, cognitive deficits following liver transplantation in children.",
author = "Garg, {Bhuwan P.} and Walsh, {Laurence E.} and Pescovitz, {Mark D.} and Hema Patel and Sonny Chong and Filo, {Ronald S.} and Joseph Fitzgerald",
year = "1993",
month = "1",
day = "1",
doi = "10.1016/0887-8994(93)90023-6",
language = "English (US)",
volume = "9",
pages = "444--448",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Neurologic complications of pediatric liver transplantation

AU - Garg, Bhuwan P.

AU - Walsh, Laurence E.

AU - Pescovitz, Mark D.

AU - Patel, Hema

AU - Chong, Sonny

AU - Filo, Ronald S.

AU - Fitzgerald, Joseph

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The neurologic complications of 24 children, ages 5 months to 18 years, following orthotopic liver transplantation at the Indiana University hospitals are reported. Biliary atresia (14 patients) was the most common cause for orthotopic liver transplantation. Three children died. Seventeen children (70%) had no neurologic deficit on follow-up 6 months or longer after transplantation. Eleven children (46%), including 4 of 16 patients (25%) who had received OKT3, had neurologic complications. Seven children (29%) had newonset seizures; 4 of these patients had status epilepticus. Two children had intracranial hemorrhage. Seizures occurred later in children than in adults following orthotopic liver transplantation and were not associated with poor prognosis. Longer term follow-up is indicated to assess subtle, cognitive deficits following liver transplantation in children.

AB - The neurologic complications of 24 children, ages 5 months to 18 years, following orthotopic liver transplantation at the Indiana University hospitals are reported. Biliary atresia (14 patients) was the most common cause for orthotopic liver transplantation. Three children died. Seventeen children (70%) had no neurologic deficit on follow-up 6 months or longer after transplantation. Eleven children (46%), including 4 of 16 patients (25%) who had received OKT3, had neurologic complications. Seven children (29%) had newonset seizures; 4 of these patients had status epilepticus. Two children had intracranial hemorrhage. Seizures occurred later in children than in adults following orthotopic liver transplantation and were not associated with poor prognosis. Longer term follow-up is indicated to assess subtle, cognitive deficits following liver transplantation in children.

UR - http://www.scopus.com/inward/record.url?scp=0027771620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027771620&partnerID=8YFLogxK

U2 - 10.1016/0887-8994(93)90023-6

DO - 10.1016/0887-8994(93)90023-6

M3 - Article

C2 - 7605552

AN - SCOPUS:0027771620

VL - 9

SP - 444

EP - 448

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

IS - 6

ER -