Neurologic complications of pediatric liver transplantation

Bhuwan P. Garg, Laurence E. Walsh, Mark D. Pescovitz, Hema Patel, Sonny Chong, Ronald S. Filo, Joseph Fitzgerald

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The neurologic complications of 24 children, ages 5 months to 18 years, following orthotopic liver transplantation at the Indiana University hospitals are reported. Biliary atresia (14 patients) was the most common cause for orthotopic liver transplantation. Three children died. Seventeen children (70%) had no neurologic deficit on follow-up 6 months or longer after transplantation. Eleven children (46%), including 4 of 16 patients (25%) who had received OKT3, had neurologic complications. Seven children (29%) had newonset seizures; 4 of these patients had status epilepticus. Two children had intracranial hemorrhage. Seizures occurred later in children than in adults following orthotopic liver transplantation and were not associated with poor prognosis. Longer term follow-up is indicated to assess subtle, cognitive deficits following liver transplantation in children.

Original languageEnglish (US)
Pages (from-to)444-448
Number of pages5
JournalPediatric Neurology
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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    Garg, B. P., Walsh, L. E., Pescovitz, M. D., Patel, H., Chong, S., Filo, R. S., & Fitzgerald, J. (1993). Neurologic complications of pediatric liver transplantation. Pediatric Neurology, 9(6), 444-448. https://doi.org/10.1016/0887-8994(93)90023-6