Neurologic paraneoplastic syndromes

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Several neurologic paraneoplastic disorders are believed to be caused by an autoimmune reaction against antigen(s) co-expressed by tumour cells and neurons. Of the paraneoplastic syndromes, the evidence for an autoimmune etiology is strongest for the Lambert-Eaton myasthenic syndrome, in which autoantibodies downregulate voltage-gated calcium channels at the presynaptic nerve terminal. For other syndromes, including cerebellar degeneration, multifocal encephalomyelitis, sensory neuronopathy, limbic encephalitis, opsoclonusmyoclonus, stiff person syndrome, and retinal degeneration, the autoimmune theory is supported by the presence of specific antineuronal antibodies. These antibodies serve as a useful diagnostic tool, but their actual role in causing neuronal injury and clinical disease remains unclear. Further understanding of immunopathogenesis awaits successful experimental models. Among different syndromes, a varied proportion of patients shows neurologic improvement with immunosuppressive treatments; it is likely that many patients have already suffered irreversible neuronal injury at the time of diagnosis.

Original languageEnglish
Pages (from-to)264-278
Number of pages15
JournalJournal of the Neurological Sciences
Volume153
Issue number2
DOIs
StatePublished - Jan 8 1998

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Nervous System Paraneoplastic Syndromes
Limbic Encephalitis
Lambert-Eaton Myasthenic Syndrome
Stiff-Person Syndrome
Cerebellar Diseases
Encephalomyelitis
Paraneoplastic Syndromes
Retinal Degeneration
Antibodies
Presynaptic Terminals
Wounds and Injuries
Calcium Channels
Immunosuppressive Agents
Nervous System Diseases
Autoantibodies
Nervous System
Theoretical Models
Down-Regulation
Neurons
Antigens

Keywords

  • Autoimmune reactions
  • Lambert-Eaton myasthenic syndrome
  • Neurologic paraneoplastic disorders

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Neurologic paraneoplastic syndromes. / Dropcho, Edward.

In: Journal of the Neurological Sciences, Vol. 153, No. 2, 08.01.1998, p. 264-278.

Research output: Contribution to journalArticle

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