Neurological complications of human immunodeficiency virus infection in patients with lymphadenopathy syndrome

R. S. Janssen, Andrew Saykin, J. E. Kaplan, T. J. Spira, P. F. Pinsky, G. C. Sprehn, J. C. Hoffman, W. B. Mayer, L. B. Schonberger

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Abstract

To determine if there is a relationship between neurological abnormalities and human immunodeficiency virus (HIV) infection in patients with lymphadenopathy syndrome (LAS), we studied 39 homosexual/bisexual men with LAS (mean duration of LAS, 4.1 yeras) and 38 homosexual/bisexual men who were seronegative for HIV (controls). Six LAS patients had histories of symptoms suggesting mononeuropathy, 9 had symptoms suggesting distal symmetrical polyneuropathy, and 9 had histories of herpes zoster radiculitis. Overall, significantly more LAS patients (18) than controls (3) had histories of symptoms or signs of neurological abnormality (odds ratio, 10.0 p = 0.0003). By neuropsychological assessment, 9 of 18 LAS patients and 2 of 26 controls were abnormal (odds ratio, 12.0; p = 0.004). Of those abnormal on the neuropsychological assessment, the majority scored in the mildly impaired range. Magnetic resonance imaging was abnormal in 1 LAS patient and in 1 control. Neither neurological nor neuropsychological abnormalities correlated with duration of LAS, absolute T-helper lymphocyte count, or T-helper/T-suppressor lymphocyte ratio. These results indicate an association of neurological and neuropsychological abnormalities with HIV in patients with LAS. They suggest that mild neurological abnormalities in LAS are common and that HIV may directly or indirectly be the cause.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalAnnals of Neurology
Volume23
Issue number1
StatePublished - 1988
Externally publishedYes

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AIDS-Related Complex
Virus Diseases
HIV
Odds Ratio
Mononeuropathies
Radiculopathy
Polyneuropathies
Herpes Zoster
Lymphocyte Count
Helper-Inducer T-Lymphocytes
Signs and Symptoms
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Janssen, R. S., Saykin, A., Kaplan, J. E., Spira, T. J., Pinsky, P. F., Sprehn, G. C., ... Schonberger, L. B. (1988). Neurological complications of human immunodeficiency virus infection in patients with lymphadenopathy syndrome. Annals of Neurology, 23(1), 49-55.

Neurological complications of human immunodeficiency virus infection in patients with lymphadenopathy syndrome. / Janssen, R. S.; Saykin, Andrew; Kaplan, J. E.; Spira, T. J.; Pinsky, P. F.; Sprehn, G. C.; Hoffman, J. C.; Mayer, W. B.; Schonberger, L. B.

In: Annals of Neurology, Vol. 23, No. 1, 1988, p. 49-55.

Research output: Contribution to journalArticle

Janssen, RS, Saykin, A, Kaplan, JE, Spira, TJ, Pinsky, PF, Sprehn, GC, Hoffman, JC, Mayer, WB & Schonberger, LB 1988, 'Neurological complications of human immunodeficiency virus infection in patients with lymphadenopathy syndrome', Annals of Neurology, vol. 23, no. 1, pp. 49-55.
Janssen, R. S. ; Saykin, Andrew ; Kaplan, J. E. ; Spira, T. J. ; Pinsky, P. F. ; Sprehn, G. C. ; Hoffman, J. C. ; Mayer, W. B. ; Schonberger, L. B. / Neurological complications of human immunodeficiency virus infection in patients with lymphadenopathy syndrome. In: Annals of Neurology. 1988 ; Vol. 23, No. 1. pp. 49-55.
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