Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain

Lixin Sun, Ai Min Hui, Qin Su, Alexander Vortmeyer, Yuri Kotliarov, Sandra Pastorino, Antonino Passaniti, Jayant Menon, Jennifer Walling, Rolando Bailey, Marc Rosenblum, Tom Mikkelsen, Howard A. Fine

Research output: Contribution to journalArticle

495 Scopus citations


Stem cell factor (SCF) is overexpressed by neurons following brain injury as well as by glioma cells; however, its role in gliomagenesis remains unclear. Here, we demonstrate that SCF directly activates brain microvascular endothelial cells (ECs) in vitro and induces a potent angiogenic response in vivo. Primary human gliomas express SCF in a grade-dependent manner and induce normal neurons to express SCF in brain regions infiltrated by glioma cells, areas that colocalize with prominent angiogenesis. Downregulation of SCF inhibits tumor-mediated angiogenesis and glioma growth in vivo, whereas overexpression of SCF is associated with shorter survival in patients with malignant gliomas. Thus, the SCF/c-Kit pathway plays an important role in tumor- and normal host cell-induced angiogenesis within the brain.

Original languageEnglish (US)
Pages (from-to)287-300
Number of pages14
JournalCancer Cell
Issue number4
StatePublished - Apr 1 2006




ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Sun, L., Hui, A. M., Su, Q., Vortmeyer, A., Kotliarov, Y., Pastorino, S., Passaniti, A., Menon, J., Walling, J., Bailey, R., Rosenblum, M., Mikkelsen, T., & Fine, H. A. (2006). Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell, 9(4), 287-300.