Neuropathy and vasculopathy in colonic strictures from children with cystic fibrosis

Margaret H. Collins, Biagio Azzarelli, Karen W. West, Sonny K F Chong, Karen M. Maguiness, John Stevens

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Colonic strictures are rare in patients who have cystic fibrosis, but recently have developed in those who have been treated with delayed-release high-dose pancreatic enzyme supplements. Colonic strictures from eight such pediatric patients showed neural abnormalities consisting of ganglion cell hyperplasia and ectopia, and intermyenteric plexus hyperplasia. Cholinergic and adrenergic stains of mucosal nerve fibers were more prominent in histological sections of the cystic fibrosis strictures than in sections from colons of children without cystic fibrosis. The mean grade of staining with acetylcholinesterase in the lamina propria of the strictured cystic fibrosis colons was 2.38 ± 1.25, compared with .93 ± .93 (P < .055) in bowels from children without cystic fibrosis. The mean grade for tyrosine hydroxylase staining in the lamina propria was 2 ± .97 in the strictures and was .79 ± .81 (P < .05) in the bowels of children who did not have cystic fibrosis. Vasoactive intestinal peptide staining in bowels from children with cystic fibrosis with and without stricture did not differ significantly from that of children without cystic fibrosis. Vasculopathy consisting of fibrointimal hyperplasia in submucosal veins and mesenteric arteries was found only in colonic strictures owing to cystic fibrosis. Colonic strictures in patients with cystic fibrosis who received high-dose pancreatic enzyme supplements contain ganglion cell abnormalities, and mucosal cholinergic and adrenergic activity may be increased in these strictures. The stricture vasculopathy may be drug-related and/or related to increased catecholamine activity.

Original languageEnglish
Pages (from-to)945-950
Number of pages6
JournalJournal of Pediatric Surgery
Volume31
Issue number7
DOIs
StatePublished - Jul 1996

Fingerprint

Cystic Fibrosis
Pathologic Constriction
Hyperplasia
Staining and Labeling
Ganglia
Adrenergic Agents
Cholinergic Agents
Colon
Mucous Membrane
Mesenteric Arteries
Vasoactive Intestinal Peptide
Tyrosine 3-Monooxygenase
Enzymes
Acetylcholinesterase
Nerve Fibers
Catecholamines
Veins
Coloring Agents
Pediatrics

Keywords

  • colonic stricture
  • Cystic fibrosis
  • neuropathy
  • pancreatic enzyme supplement
  • vasculopathy

ASJC Scopus subject areas

  • Surgery

Cite this

Neuropathy and vasculopathy in colonic strictures from children with cystic fibrosis. / Collins, Margaret H.; Azzarelli, Biagio; West, Karen W.; Chong, Sonny K F; Maguiness, Karen M.; Stevens, John.

In: Journal of Pediatric Surgery, Vol. 31, No. 7, 07.1996, p. 945-950.

Research output: Contribution to journalArticle

Collins, Margaret H. ; Azzarelli, Biagio ; West, Karen W. ; Chong, Sonny K F ; Maguiness, Karen M. ; Stevens, John. / Neuropathy and vasculopathy in colonic strictures from children with cystic fibrosis. In: Journal of Pediatric Surgery. 1996 ; Vol. 31, No. 7. pp. 945-950.
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