NEUROPATHY, M COMPONENTS, AND AMYLOID

Merrill Benson, KennethD Brandt, AlanS Cohen, EdgarS Cathcart

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Of eighty-seven patients with non-hereditary systemic amyloidosis, ten had evidence of peripheral neuropathy. There was median-nerve neuropathy due to infiltration of the flexor retinaculum with amyloid in six patients. Two patients had diffuse sensorimotor neuropathy and two patients had sensory loss without evidence of motor impairment-three of these cases had amyloid deposition demonstrated by nerve biopsy. Neurological manifestations in all ten patients preceded other evidence of amyloidosis by 6 months-4 years (mean, 1·5 years). Neuropathy occurred in six of thirty-eight patients with primary amyloidosis and four of fourteen with amyloidosis associated with malignant B-cell dyscrasias; and all patients with neuropathy had either a serum-M-component or Bence-Jones proteinuria. In contrast, neuropathy was not noted in any of the fifty-six patients in this series who had no evidence of a monoclonal gammopathy (thirty-five with secondary and twenty-one with primary amyloidosis).

Original languageEnglish (US)
Pages (from-to)10-12
Number of pages3
JournalThe Lancet
Volume305
Issue number7897
DOIs
StatePublished - Jan 4 1975
Externally publishedYes

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Myeloma Proteins
Amyloid
Amyloidosis
Median Neuropathy
Paraproteinemias
Median Nerve
Peripheral Nervous System Diseases
Neurologic Manifestations
Proteinuria
B-Lymphocytes
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Benson, M., Brandt, K., Cohen, A., & Cathcart, E. (1975). NEUROPATHY, M COMPONENTS, AND AMYLOID. The Lancet, 305(7897), 10-12. https://doi.org/10.1016/S0140-6736(75)92373-9

NEUROPATHY, M COMPONENTS, AND AMYLOID. / Benson, Merrill; Brandt, KennethD; Cohen, AlanS; Cathcart, EdgarS.

In: The Lancet, Vol. 305, No. 7897, 04.01.1975, p. 10-12.

Research output: Contribution to journalArticle

Benson, M, Brandt, K, Cohen, A & Cathcart, E 1975, 'NEUROPATHY, M COMPONENTS, AND AMYLOID', The Lancet, vol. 305, no. 7897, pp. 10-12. https://doi.org/10.1016/S0140-6736(75)92373-9
Benson, Merrill ; Brandt, KennethD ; Cohen, AlanS ; Cathcart, EdgarS. / NEUROPATHY, M COMPONENTS, AND AMYLOID. In: The Lancet. 1975 ; Vol. 305, No. 7897. pp. 10-12.
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