Neuropeptide signaling of lymphocytes in immunological responses

Edward J. Goetzl, Menghang Xia, David Ingram, Jeffrey L. Kishiyama, H. Benfer Kaltreider, Patricia K. Byrd, Sanae Ichikawa, Sunil P. Sreedharan

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Peptidergic nerves in immune organs and lymphoid tissues of the lungs and gastrointestinal tract end on or in close proximity to lymphocytes, mast cells and macrophages. Vasoactive intestinal peptide, substance P and some other neuropeptides, that are recognized by distinct sets of cell surface receptors, regulate aspects of T cell differentiation in the thymus, such as negative selection, and contribute to mediating compartmental immune responses. The latter effects include stimulating expression of adhesive proteins by lymphocytes, enhancement of lymphocyte and macrophage migration in vascular and connectivc tissues, and modulation of proliferative and synthetic responses of lymphocytes to diverse antigens.

Original languageEnglish (US)
Pages (from-to)202-204
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume107
Issue number1-3
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Neuropeptides
Lymphocytes
Macrophages
Vasoactive Intestinal Peptide
Cell Surface Receptors
Lymphoid Tissue
Substance P
Mast Cells
Adhesives
Thymus Gland
Blood Vessels
Gastrointestinal Tract
Cell Differentiation
T-Lymphocytes
Antigens
Lung
Proteins

Keywords

  • Chemotaxis
  • Cytokine
  • Immunoglobulin
  • Neuropeptide receptor Apoptosis
  • Substance P
  • T cell
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Goetzl, E. J., Xia, M., Ingram, D., Kishiyama, J. L., Kaltreider, H. B., Byrd, P. K., ... Sreedharan, S. P. (1995). Neuropeptide signaling of lymphocytes in immunological responses. International Archives of Allergy and Immunology, 107(1-3), 202-204. https://doi.org/10.1159/000236977

Neuropeptide signaling of lymphocytes in immunological responses. / Goetzl, Edward J.; Xia, Menghang; Ingram, David; Kishiyama, Jeffrey L.; Kaltreider, H. Benfer; Byrd, Patricia K.; Ichikawa, Sanae; Sreedharan, Sunil P.

In: International Archives of Allergy and Immunology, Vol. 107, No. 1-3, 1995, p. 202-204.

Research output: Contribution to journalArticle

Goetzl, EJ, Xia, M, Ingram, D, Kishiyama, JL, Kaltreider, HB, Byrd, PK, Ichikawa, S & Sreedharan, SP 1995, 'Neuropeptide signaling of lymphocytes in immunological responses', International Archives of Allergy and Immunology, vol. 107, no. 1-3, pp. 202-204. https://doi.org/10.1159/000236977
Goetzl, Edward J. ; Xia, Menghang ; Ingram, David ; Kishiyama, Jeffrey L. ; Kaltreider, H. Benfer ; Byrd, Patricia K. ; Ichikawa, Sanae ; Sreedharan, Sunil P. / Neuropeptide signaling of lymphocytes in immunological responses. In: International Archives of Allergy and Immunology. 1995 ; Vol. 107, No. 1-3. pp. 202-204.
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