Neuropeptide signaling of lymphocytes in immunological responses

Edward J. Goetzl, Menghang Xia, David A. Ingram, Jeffrey L. Kishiyama, H. Benfer Kaltreider, Patricia K. Byrd, Sanae Ichikawa, Sunil P. Sreedharan

Research output: Contribution to journalArticle

28 Scopus citations


Peptidergic nerves in immune organs and lymphoid tissues of the lungs and gastrointestinal tract end on or in close proximity to lymphocytes, mast cells and macrophages. Vasoactive intestinal peptide, substance P and some other neuropeptides, that are recognized by distinct sets of cell surface receptors, regulate aspects of T cell differentiation in the thymus, such as negative selection, and contribute to mediating compartmental immune responses. The latter effects include stimulating expression of adhesive proteins by lymphocytes, enhancement of lymphocyte and macrophage migration in vascular and connectivc tissues, and modulation of proliferative and synthetic responses of lymphocytes to diverse antigens.

Original languageEnglish (US)
Pages (from-to)202-204
Number of pages3
JournalInternational Archives of Allergy and Immunology
Issue number1-3
StatePublished - Jan 1 1995
Externally publishedYes


  • Chemotaxis
  • Cytokine
  • Immunoglobulin
  • Neuropeptide receptor Apoptosis
  • Substance P
  • T cell
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Neuropeptide signaling of lymphocytes in immunological responses'. Together they form a unique fingerprint.

  • Cite this

    Goetzl, E. J., Xia, M., Ingram, D. A., Kishiyama, J. L., Kaltreider, H. B., Byrd, P. K., Ichikawa, S., & Sreedharan, S. P. (1995). Neuropeptide signaling of lymphocytes in immunological responses. International Archives of Allergy and Immunology, 107(1-3), 202-204.