Neuropeptide Y (NPY) immunoreactivity has been determined in human cerebrospinal fluid (CSF). High pressure liquid chromatography revealed that the NPY immunoreactivity co-eluted with authentic NPY. The range of NPY levels was 108±18 pg/ml (mean±S.D.) in a group of 28 normal subjects. In five additional subjects NPY immunoreactivity was measured in 4 sequential 8 ml aliquots of CSF to determine whether a rostro-caudal gradient was present. No significant differences in NPY levels were detected between any of the 4 aliquots.
- Human cerebrospinal fluid (CSF)
- Human studies
- Neuropeptide Y immunoreactivity (NPY)
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience