Neuropeptides in human cerebrospinal fluid

Wade H. Berrettini, John I. Nurnberger, Philip W. Gold, Michel Chretien, George P. Chrousos, J. S.D. Chan, Lynn R. Goldin, Elliot S. Gershon

Research output: Contribution to journalArticle

27 Scopus citations


Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) were highly, positively correlated with one another. This result is consistent with the hypothesis that cerebrospinal fluid levels of these seven peptides are a function of some common regulatory factor, such as shared release into the cerebrospinal fluid.

Original languageEnglish (US)
Pages (from-to)1265-1270
Number of pages6
JournalLife Sciences
Issue number13
StatePublished - Sep 30 1985
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Berrettini, W. H., Nurnberger, J. I., Gold, P. W., Chretien, M., Chrousos, G. P., Chan, J. S. D., Goldin, L. R., & Gershon, E. S. (1985). Neuropeptides in human cerebrospinal fluid. Life Sciences, 37(13), 1265-1270.