Neurophysiological changes associated with selective neuronal damage in hippocampus following transient forebrain ischemia

Z. C. Xu, T. M. Gao, Y. Ren

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Neurophysiological changes of hippocampal neurons were compared before and after transient forebrain ischemia using intracellular recording and staining techniques in vivo. Ischemic depolarization (ID) was used as an indication of severe ischemia. Under halothane anesthesia, approximately 13 min of ID consistently produced severe neuronal damage in the CA1 region of rat hippocampus, while CA3 pyramidal neurons and dentate granule cells remained intact. After such severe ischemia, approximately 60% of the CA1 neurons exhibited a synaptic potentiation. The excitability of these neurons progressively decreased following reperfusion. Approximately 30% of the CA1 neurons showed a synaptic depression following ischemia. The excitability of these neurons transiently decreased following reperfusion. After ischemia of the same severity, both synaptic transmission and excitability of CA3 and granule cells transiently depressed. These data suggest that ischemia-induced synaptic potentiation may be associated with the pathogenesis of neuronal damage following ischemia, and that the synaptic depression may have protective effects on hippocampal neurons after ischemic insult.

Original languageEnglish
Pages (from-to)294-308
Number of pages15
JournalBiological Signals and Receptors
Volume8
Issue number4-5
StatePublished - 1999

Fingerprint

Prosencephalon
Neurons
Hippocampus
Ischemia
Depolarization
Reperfusion
Pyramidal Cells
Halothane
Synaptic Transmission
Rats
Anesthesia
Staining and Labeling

Keywords

  • Excitotoxicity
  • Hippocampus
  • In vivo intracellular recording
  • Ischemia
  • Synaptic depression
  • Synaptic potentiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Neurophysiological changes associated with selective neuronal damage in hippocampus following transient forebrain ischemia. / Xu, Z. C.; Gao, T. M.; Ren, Y.

In: Biological Signals and Receptors, Vol. 8, No. 4-5, 1999, p. 294-308.

Research output: Contribution to journalArticle

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