Neurophysiology and neuropharmacology of cardiovascular regulation and stress

Richard A. Galosy, Lewis K. Clarke, Michael R. Vasko, Isaac L. Crawford

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


Evidence has accumulated over the past several years indicating that environmental factors can have a substantial influence on cardiovascular dynamics. It has been hypothesized by many investigators that through these influences environmental stressors may be important to the etiology and maintenance of cardiovascular diseases. Since the nervous system is intimately involved in the regulation of cardiovascular function it may be assumed that environmental influences on cardiovascular dynamics are to a large extent mediated by the nervous system. This assumption is supported by the literature reviewed which indicates that there are many nervous system nuclei and neurotransmitter systems involved in the regulation of cardiovascular dynamics which are also involved in an organisms adjustment to environmental stressors. The conclusion is reached that further multidisciplinary research will reveal underlying neurophysiological and neuropharmacological mechanisms responsible for stress induced cardiovascular disease and lead to new methods of treatment.

Original languageEnglish (US)
Pages (from-to)137-175
Number of pages39
JournalNeuroscience and Biobehavioral Reviews
Issue number1
StatePublished - Jan 1 1981
Externally publishedYes


  • Autonomic nervous system
  • Behavioral stress
  • Blood pressure
  • Cardiovascular regulation
  • Central nervous system
  • Heart rate
  • Hypertension
  • Neuroanatomy
  • Neuropharmacology
  • Neurophysiology
  • Neurotoxins
  • Neurotransmitters
  • Spontaneous hypertension

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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