Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics

Katsuyoshi Shimizu, Nishadi Rajapakse, Takashi Horiguchi, R. Payne, David W. Busija

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We investigated the effects of two new low molecular weight nonpeptidyl superoxide dismutase (SOD) mimetics (M40403/M40401; MetaPhore Pharmaceuticals) on infarct volume after hypoxia-ischemia injury (H/I) in immature rats. Animals received vehicle or different doses of M40403 or M40401 i.p. 2 h before exposure to 3 h of 8% hypoxia. The infarct volume of the hemisphere ipsilateral to carotid ligation 24 h later was 73.9±8.9% in vehicle animals (n=9), and decreased to 39.7±7.2% (P

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Volume346
Issue number1-2
DOIs
StatePublished - Jul 31 2003
Externally publishedYes

Fingerprint

Superoxide Dismutase
Ischemia
Brain
Ligation
Molecular Weight
Wounds and Injuries
Pharmaceutical Preparations
imisopasem manganese
Neuroprotection
M40401
Hypoxia

Keywords

  • Brain injury
  • Neonate
  • Reactive oxygen species
  • Superoxide anion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics. / Shimizu, Katsuyoshi; Rajapakse, Nishadi; Horiguchi, Takashi; Payne, R.; Busija, David W.

In: Neuroscience Letters, Vol. 346, No. 1-2, 31.07.2003, p. 41-44.

Research output: Contribution to journalArticle

Shimizu, Katsuyoshi ; Rajapakse, Nishadi ; Horiguchi, Takashi ; Payne, R. ; Busija, David W. / Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics. In: Neuroscience Letters. 2003 ; Vol. 346, No. 1-2. pp. 41-44.
@article{288abcab7ba043bab6cfd9298afdd71b,
title = "Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics",
abstract = "We investigated the effects of two new low molecular weight nonpeptidyl superoxide dismutase (SOD) mimetics (M40403/M40401; MetaPhore Pharmaceuticals) on infarct volume after hypoxia-ischemia injury (H/I) in immature rats. Animals received vehicle or different doses of M40403 or M40401 i.p. 2 h before exposure to 3 h of 8{\%} hypoxia. The infarct volume of the hemisphere ipsilateral to carotid ligation 24 h later was 73.9±8.9{\%} in vehicle animals (n=9), and decreased to 39.7±7.2{\%} (P",
keywords = "Brain injury, Neonate, Reactive oxygen species, Superoxide anion",
author = "Katsuyoshi Shimizu and Nishadi Rajapakse and Takashi Horiguchi and R. Payne and Busija, {David W.}",
year = "2003",
month = "7",
day = "31",
doi = "10.1016/S0304-3940(03)00558-5",
language = "English (US)",
volume = "346",
pages = "41--44",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics

AU - Shimizu, Katsuyoshi

AU - Rajapakse, Nishadi

AU - Horiguchi, Takashi

AU - Payne, R.

AU - Busija, David W.

PY - 2003/7/31

Y1 - 2003/7/31

N2 - We investigated the effects of two new low molecular weight nonpeptidyl superoxide dismutase (SOD) mimetics (M40403/M40401; MetaPhore Pharmaceuticals) on infarct volume after hypoxia-ischemia injury (H/I) in immature rats. Animals received vehicle or different doses of M40403 or M40401 i.p. 2 h before exposure to 3 h of 8% hypoxia. The infarct volume of the hemisphere ipsilateral to carotid ligation 24 h later was 73.9±8.9% in vehicle animals (n=9), and decreased to 39.7±7.2% (P

AB - We investigated the effects of two new low molecular weight nonpeptidyl superoxide dismutase (SOD) mimetics (M40403/M40401; MetaPhore Pharmaceuticals) on infarct volume after hypoxia-ischemia injury (H/I) in immature rats. Animals received vehicle or different doses of M40403 or M40401 i.p. 2 h before exposure to 3 h of 8% hypoxia. The infarct volume of the hemisphere ipsilateral to carotid ligation 24 h later was 73.9±8.9% in vehicle animals (n=9), and decreased to 39.7±7.2% (P

KW - Brain injury

KW - Neonate

KW - Reactive oxygen species

KW - Superoxide anion

UR - http://www.scopus.com/inward/record.url?scp=0038045431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038045431&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(03)00558-5

DO - 10.1016/S0304-3940(03)00558-5

M3 - Article

C2 - 12850543

AN - SCOPUS:0038045431

VL - 346

SP - 41

EP - 44

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -