Neuroprotective actions of androgens on motoneurons

Keith N. Fargo, Eileen M. Foecking, Kathryn Jones, Dale R. Sengelaub

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Androgens have a variety of protective and therapeutic effects in both the central and peripheral nervous systems. Here we review these effects as they related specifically to spinal and cranial motoneurons. Early in development, androgens are critical for the formation of important neuromuscular sex differences, decreasing the magnitude of normally occurring cell death in select motoneuron populations. Throughout the lifespan, androgens also protect against motoneuron death caused by axonal injury. Surviving motoneurons also display regressive changes to their neurites as a result of both direct axonal injury and loss of neighboring motoneurons. Androgen treatment enhances the ability of motoneurons to recover from these regressive changes and regenerate both axons and dendrites, restoring normal neuromuscular function. Androgens exert these protective effects by acting through a variety of molecular pathways. Recent work has begun to examine how androgen treatment can interact with other treatment strategies in promoting recovery from motoneuron injury.

Original languageEnglish (US)
Pages (from-to)130-141
Number of pages12
JournalFrontiers in Neuroendocrinology
Volume30
Issue number2
DOIs
StatePublished - Jul 2009
Externally publishedYes

Fingerprint

Motor Neurons
Androgens
Wounds and Injuries
Peripheral Nervous System
Therapeutic Uses
Neurites
Dendrites
Sex Characteristics
Axons
Cell Death
Central Nervous System
Population

Keywords

  • Androgens
  • Axotomy
  • Cell death
  • Dendrites
  • Motoneurons
  • Nerve regeneration
  • Neuroprotection
  • Sex differences
  • Steroids
  • Testosterone

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems

Cite this

Neuroprotective actions of androgens on motoneurons. / Fargo, Keith N.; Foecking, Eileen M.; Jones, Kathryn; Sengelaub, Dale R.

In: Frontiers in Neuroendocrinology, Vol. 30, No. 2, 07.2009, p. 130-141.

Research output: Contribution to journalArticle

Fargo, Keith N. ; Foecking, Eileen M. ; Jones, Kathryn ; Sengelaub, Dale R. / Neuroprotective actions of androgens on motoneurons. In: Frontiers in Neuroendocrinology. 2009 ; Vol. 30, No. 2. pp. 130-141.
@article{e3cbd0983cb34d4683f18e61dc8bd4e7,
title = "Neuroprotective actions of androgens on motoneurons",
abstract = "Androgens have a variety of protective and therapeutic effects in both the central and peripheral nervous systems. Here we review these effects as they related specifically to spinal and cranial motoneurons. Early in development, androgens are critical for the formation of important neuromuscular sex differences, decreasing the magnitude of normally occurring cell death in select motoneuron populations. Throughout the lifespan, androgens also protect against motoneuron death caused by axonal injury. Surviving motoneurons also display regressive changes to their neurites as a result of both direct axonal injury and loss of neighboring motoneurons. Androgen treatment enhances the ability of motoneurons to recover from these regressive changes and regenerate both axons and dendrites, restoring normal neuromuscular function. Androgens exert these protective effects by acting through a variety of molecular pathways. Recent work has begun to examine how androgen treatment can interact with other treatment strategies in promoting recovery from motoneuron injury.",
keywords = "Androgens, Axotomy, Cell death, Dendrites, Motoneurons, Nerve regeneration, Neuroprotection, Sex differences, Steroids, Testosterone",
author = "Fargo, {Keith N.} and Foecking, {Eileen M.} and Kathryn Jones and Sengelaub, {Dale R.}",
year = "2009",
month = "7",
doi = "10.1016/j.yfrne.2009.04.005",
language = "English (US)",
volume = "30",
pages = "130--141",
journal = "Frontiers in Neuroendocrinology",
issn = "0091-3022",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Neuroprotective actions of androgens on motoneurons

AU - Fargo, Keith N.

AU - Foecking, Eileen M.

AU - Jones, Kathryn

AU - Sengelaub, Dale R.

PY - 2009/7

Y1 - 2009/7

N2 - Androgens have a variety of protective and therapeutic effects in both the central and peripheral nervous systems. Here we review these effects as they related specifically to spinal and cranial motoneurons. Early in development, androgens are critical for the formation of important neuromuscular sex differences, decreasing the magnitude of normally occurring cell death in select motoneuron populations. Throughout the lifespan, androgens also protect against motoneuron death caused by axonal injury. Surviving motoneurons also display regressive changes to their neurites as a result of both direct axonal injury and loss of neighboring motoneurons. Androgen treatment enhances the ability of motoneurons to recover from these regressive changes and regenerate both axons and dendrites, restoring normal neuromuscular function. Androgens exert these protective effects by acting through a variety of molecular pathways. Recent work has begun to examine how androgen treatment can interact with other treatment strategies in promoting recovery from motoneuron injury.

AB - Androgens have a variety of protective and therapeutic effects in both the central and peripheral nervous systems. Here we review these effects as they related specifically to spinal and cranial motoneurons. Early in development, androgens are critical for the formation of important neuromuscular sex differences, decreasing the magnitude of normally occurring cell death in select motoneuron populations. Throughout the lifespan, androgens also protect against motoneuron death caused by axonal injury. Surviving motoneurons also display regressive changes to their neurites as a result of both direct axonal injury and loss of neighboring motoneurons. Androgen treatment enhances the ability of motoneurons to recover from these regressive changes and regenerate both axons and dendrites, restoring normal neuromuscular function. Androgens exert these protective effects by acting through a variety of molecular pathways. Recent work has begun to examine how androgen treatment can interact with other treatment strategies in promoting recovery from motoneuron injury.

KW - Androgens

KW - Axotomy

KW - Cell death

KW - Dendrites

KW - Motoneurons

KW - Nerve regeneration

KW - Neuroprotection

KW - Sex differences

KW - Steroids

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=67349227134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349227134&partnerID=8YFLogxK

U2 - 10.1016/j.yfrne.2009.04.005

DO - 10.1016/j.yfrne.2009.04.005

M3 - Article

VL - 30

SP - 130

EP - 141

JO - Frontiers in Neuroendocrinology

JF - Frontiers in Neuroendocrinology

SN - 0091-3022

IS - 2

ER -