Neuroprotective effects of gonadal steroids on regenerating peripheral motoneurons

Kathryn J. Jones, Todd J. Brown, Margot Damaser

Research output: Contribution to journalArticle

92 Scopus citations


In this review, the neuroprotective actions of testosterone on three different populations of injured rat peripheral motoneurons, i.e. facial (FMN), spinal (SMN) and pudendal (PMN), will be discussed. We have extrapolated concepts from the neuroendocrine field regarding the trophic effects of gonadal steroids on target neural tissue to the nerve regeneration field. Exogenous administration of testosterone immediately after nerve injury impacts positively on functional recovery through actions mediated by the androgen receptor. The mechanism by which steroidal enhancement of the regenerative properties of injured motoneurons occurs may involve pre-existing androgen receptors, heat shock proteins, and modulation of the cellular stress response.

Original languageEnglish (US)
Pages (from-to)372-382
Number of pages11
JournalBrain Research Reviews
Issue number1-3
StatePublished - Dec 1 2001
Externally publishedYes


  • Estradiol
  • Facial nerve
  • Pudendal nerve
  • Sciatic nerve
  • Stress response
  • Testosterone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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