Neuroprotective effects of gonadal steroids on regenerating peripheral motoneurons

Kathryn Jones, Todd J. Brown, Margot Damaser

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

In this review, the neuroprotective actions of testosterone on three different populations of injured rat peripheral motoneurons, i.e. facial (FMN), spinal (SMN) and pudendal (PMN), will be discussed. We have extrapolated concepts from the neuroendocrine field regarding the trophic effects of gonadal steroids on target neural tissue to the nerve regeneration field. Exogenous administration of testosterone immediately after nerve injury impacts positively on functional recovery through actions mediated by the androgen receptor. The mechanism by which steroidal enhancement of the regenerative properties of injured motoneurons occurs may involve pre-existing androgen receptors, heat shock proteins, and modulation of the cellular stress response.

Original languageEnglish (US)
Pages (from-to)372-382
Number of pages11
JournalBrain Research Reviews
Volume37
Issue number1-3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Androgen Receptors
Motor Neurons
Neuroprotective Agents
Testosterone
Steroids
Flavin Mononucleotide
Nerve Regeneration
Heat-Shock Proteins
Wounds and Injuries
Population

Keywords

  • Estradiol
  • Facial nerve
  • Pudendal nerve
  • Sciatic nerve
  • Stress response
  • Testosterone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuroprotective effects of gonadal steroids on regenerating peripheral motoneurons. / Jones, Kathryn; Brown, Todd J.; Damaser, Margot.

In: Brain Research Reviews, Vol. 37, No. 1-3, 2001, p. 372-382.

Research output: Contribution to journalArticle

Jones, Kathryn ; Brown, Todd J. ; Damaser, Margot. / Neuroprotective effects of gonadal steroids on regenerating peripheral motoneurons. In: Brain Research Reviews. 2001 ; Vol. 37, No. 1-3. pp. 372-382.
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