Neuropsychologic Outcomes in a Case Series of Twins Discordant for Perinatal Stroke

Tasneem L. Talib, Stephen J. Pongonis, Linda Williams, Bhuwan P. Garg, Deborah Sokol, Chandan Saha, Meredith Golomb

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Perinatal stroke may affect cognitive development, but few studies have addressed the details of cognitive function after perinatal stroke. The present study was designed to compare the neuropsychologic features of five sets of twins discordant for perinatal stroke. All of the affected children had unilateral middle cerebral artery infarction (two left, three right); four of the five infarcts were large-branch, affecting the entire M1 territory. Three of the five affected children had comorbid epilepsy. Measures of intelligence, memory, language, attention, executive function, visual-motor integration, and fine motor skills were administered to children at a median age of 5 years (range, 5-8 years). Relative to their unaffected co-twins, the twins with perinatal stroke exhibited lower levels of full scale (p = 0.005), verbal (p = 0.006), and nonverbal (p = 0.005) intelligence. Children with perinatal stroke also showed significant deficits on tests of verbal memory (p = 0.041), receptive language (p = 0.011), verbal fluency (p = 0.019), and visual attention (p = 0.011), compared with their unaffected co-twins. Twin gestation may be a risk factor for poor cognitive outcome after perinatal stroke. Large infarct size and comorbid epilepsy may have contributed to some of the poor cognitive outcomes in this cohort.

Original languageEnglish
Pages (from-to)118-125
Number of pages8
JournalPediatric Neurology
Volume38
Issue number2
DOIs
StatePublished - Feb 2008

Fingerprint

Stroke
Intelligence
Epilepsy
Language
Motor Skills
Middle Cerebral Artery Infarction
Executive Function
Cognition
Pregnancy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Neuropsychologic Outcomes in a Case Series of Twins Discordant for Perinatal Stroke. / Talib, Tasneem L.; Pongonis, Stephen J.; Williams, Linda; Garg, Bhuwan P.; Sokol, Deborah; Saha, Chandan; Golomb, Meredith.

In: Pediatric Neurology, Vol. 38, No. 2, 02.2008, p. 118-125.

Research output: Contribution to journalArticle

@article{da103eee9a0348518b8cd7edc358f12f,
title = "Neuropsychologic Outcomes in a Case Series of Twins Discordant for Perinatal Stroke",
abstract = "Perinatal stroke may affect cognitive development, but few studies have addressed the details of cognitive function after perinatal stroke. The present study was designed to compare the neuropsychologic features of five sets of twins discordant for perinatal stroke. All of the affected children had unilateral middle cerebral artery infarction (two left, three right); four of the five infarcts were large-branch, affecting the entire M1 territory. Three of the five affected children had comorbid epilepsy. Measures of intelligence, memory, language, attention, executive function, visual-motor integration, and fine motor skills were administered to children at a median age of 5 years (range, 5-8 years). Relative to their unaffected co-twins, the twins with perinatal stroke exhibited lower levels of full scale (p = 0.005), verbal (p = 0.006), and nonverbal (p = 0.005) intelligence. Children with perinatal stroke also showed significant deficits on tests of verbal memory (p = 0.041), receptive language (p = 0.011), verbal fluency (p = 0.019), and visual attention (p = 0.011), compared with their unaffected co-twins. Twin gestation may be a risk factor for poor cognitive outcome after perinatal stroke. Large infarct size and comorbid epilepsy may have contributed to some of the poor cognitive outcomes in this cohort.",
author = "Talib, {Tasneem L.} and Pongonis, {Stephen J.} and Linda Williams and Garg, {Bhuwan P.} and Deborah Sokol and Chandan Saha and Meredith Golomb",
year = "2008",
month = "2",
doi = "10.1016/j.pediatrneurol.2007.10.002",
language = "English",
volume = "38",
pages = "118--125",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Neuropsychologic Outcomes in a Case Series of Twins Discordant for Perinatal Stroke

AU - Talib, Tasneem L.

AU - Pongonis, Stephen J.

AU - Williams, Linda

AU - Garg, Bhuwan P.

AU - Sokol, Deborah

AU - Saha, Chandan

AU - Golomb, Meredith

PY - 2008/2

Y1 - 2008/2

N2 - Perinatal stroke may affect cognitive development, but few studies have addressed the details of cognitive function after perinatal stroke. The present study was designed to compare the neuropsychologic features of five sets of twins discordant for perinatal stroke. All of the affected children had unilateral middle cerebral artery infarction (two left, three right); four of the five infarcts were large-branch, affecting the entire M1 territory. Three of the five affected children had comorbid epilepsy. Measures of intelligence, memory, language, attention, executive function, visual-motor integration, and fine motor skills were administered to children at a median age of 5 years (range, 5-8 years). Relative to their unaffected co-twins, the twins with perinatal stroke exhibited lower levels of full scale (p = 0.005), verbal (p = 0.006), and nonverbal (p = 0.005) intelligence. Children with perinatal stroke also showed significant deficits on tests of verbal memory (p = 0.041), receptive language (p = 0.011), verbal fluency (p = 0.019), and visual attention (p = 0.011), compared with their unaffected co-twins. Twin gestation may be a risk factor for poor cognitive outcome after perinatal stroke. Large infarct size and comorbid epilepsy may have contributed to some of the poor cognitive outcomes in this cohort.

AB - Perinatal stroke may affect cognitive development, but few studies have addressed the details of cognitive function after perinatal stroke. The present study was designed to compare the neuropsychologic features of five sets of twins discordant for perinatal stroke. All of the affected children had unilateral middle cerebral artery infarction (two left, three right); four of the five infarcts were large-branch, affecting the entire M1 territory. Three of the five affected children had comorbid epilepsy. Measures of intelligence, memory, language, attention, executive function, visual-motor integration, and fine motor skills were administered to children at a median age of 5 years (range, 5-8 years). Relative to their unaffected co-twins, the twins with perinatal stroke exhibited lower levels of full scale (p = 0.005), verbal (p = 0.006), and nonverbal (p = 0.005) intelligence. Children with perinatal stroke also showed significant deficits on tests of verbal memory (p = 0.041), receptive language (p = 0.011), verbal fluency (p = 0.019), and visual attention (p = 0.011), compared with their unaffected co-twins. Twin gestation may be a risk factor for poor cognitive outcome after perinatal stroke. Large infarct size and comorbid epilepsy may have contributed to some of the poor cognitive outcomes in this cohort.

UR - http://www.scopus.com/inward/record.url?scp=38149082708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149082708&partnerID=8YFLogxK

U2 - 10.1016/j.pediatrneurol.2007.10.002

DO - 10.1016/j.pediatrneurol.2007.10.002

M3 - Article

C2 - 18206793

AN - SCOPUS:38149082708

VL - 38

SP - 118

EP - 125

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

IS - 2

ER -