Neuropsychological dysfunction in HIV-infection: Characterization in a lymphadenopathy cohort

A. J. Saykin, R. S. Janssen, G. C. Sprehn, J. E. Kaplan, T. J. Spira, P. Weller

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Abstract

Comprehensive neuropsychological testing was administered to HIV seropositive gay men with lymphadenopathy syndrome (LAS). Nine of 18 LAS cases (50%) and 2 of 26 seronegative controls (8%) were abnormal by blind clinical rating (Fisher Exact Test, p=.003). Deficits were generally mild and in the areas of language (naming and fluency), attention, visual and auditory information processing, psychomotor speed and memory. These deficits, contrasted with relatively preserved higher level conceptual skills, are generally compatible with the pattern of impairment and predominately subcortical pathology described in AIDS dementia. There was a trend toward higher anxiety and depression scores in the abnormal cases, but neuropsychological dysfunction was not attributable to affective factors. Abnormal cases also had higher elevations on MMPI-168 measures of somatic complaints. Neuropsychological findings did not correlate with duration of LAS, absolute T helper values, or with MRI volumetric measures, indicating that psychometric testing may provide the first sign of CNS involvement in HIV infection.

Original languageEnglish (US)
Pages (from-to)81-95
Number of pages15
JournalInternational Journal of Clinical Neuropsychology
Volume10
Issue number2
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Applied Psychology
  • Psychiatry and Mental health

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