Neuropsychological dysfunction in HIV-infection

Characterization in a lymphadenopathy cohort

Andrew Saykin, R. S. Janssen, G. C. Sprehn, J. E. Kaplan, T. J. Spira, P. Weller

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Comprehensive neuropsychological testing was administered to HIV seropositive gay men with lymphadenopathy syndrome (LAS). Nine of 18 LAS cases (50%) and 2 of 26 seronegative controls (8%) were abnormal by blind clinical rating (Fisher Exact Test, p=.003). Deficits were generally mild and in the areas of language (naming and fluency), attention, visual and auditory information processing, psychomotor speed and memory. These deficits, contrasted with relatively preserved higher level conceptual skills, are generally compatible with the pattern of impairment and predominately subcortical pathology described in AIDS dementia. There was a trend toward higher anxiety and depression scores in the abnormal cases, but neuropsychological dysfunction was not attributable to affective factors. Abnormal cases also had higher elevations on MMPI-168 measures of somatic complaints. Neuropsychological findings did not correlate with duration of LAS, absolute T helper values, or with MRI volumetric measures, indicating that psychometric testing may provide the first sign of CNS involvement in HIV infection.

Original languageEnglish (US)
Pages (from-to)81-95
Number of pages15
JournalInternational Journal of Clinical Neuropsychology
Volume10
Issue number2
StatePublished - 1988
Externally publishedYes

Fingerprint

AIDS-Related Complex
HIV Infections
MMPI
Automatic Data Processing
Psychometrics
Dementia
Acquired Immunodeficiency Syndrome
Language
Anxiety
HIV
Depression
Pathology
Lymphadenopathy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology
  • Neuropsychology and Physiological Psychology

Cite this

Neuropsychological dysfunction in HIV-infection : Characterization in a lymphadenopathy cohort. / Saykin, Andrew; Janssen, R. S.; Sprehn, G. C.; Kaplan, J. E.; Spira, T. J.; Weller, P.

In: International Journal of Clinical Neuropsychology, Vol. 10, No. 2, 1988, p. 81-95.

Research output: Contribution to journalArticle

Saykin, Andrew ; Janssen, R. S. ; Sprehn, G. C. ; Kaplan, J. E. ; Spira, T. J. ; Weller, P. / Neuropsychological dysfunction in HIV-infection : Characterization in a lymphadenopathy cohort. In: International Journal of Clinical Neuropsychology. 1988 ; Vol. 10, No. 2. pp. 81-95.
@article{1b72c891a4e844d0a6e794968a4fd047,
title = "Neuropsychological dysfunction in HIV-infection: Characterization in a lymphadenopathy cohort",
abstract = "Comprehensive neuropsychological testing was administered to HIV seropositive gay men with lymphadenopathy syndrome (LAS). Nine of 18 LAS cases (50{\%}) and 2 of 26 seronegative controls (8{\%}) were abnormal by blind clinical rating (Fisher Exact Test, p=.003). Deficits were generally mild and in the areas of language (naming and fluency), attention, visual and auditory information processing, psychomotor speed and memory. These deficits, contrasted with relatively preserved higher level conceptual skills, are generally compatible with the pattern of impairment and predominately subcortical pathology described in AIDS dementia. There was a trend toward higher anxiety and depression scores in the abnormal cases, but neuropsychological dysfunction was not attributable to affective factors. Abnormal cases also had higher elevations on MMPI-168 measures of somatic complaints. Neuropsychological findings did not correlate with duration of LAS, absolute T helper values, or with MRI volumetric measures, indicating that psychometric testing may provide the first sign of CNS involvement in HIV infection.",
author = "Andrew Saykin and Janssen, {R. S.} and Sprehn, {G. C.} and Kaplan, {J. E.} and Spira, {T. J.} and P. Weller",
year = "1988",
language = "English (US)",
volume = "10",
pages = "81--95",
journal = "Clinical Neuropsychology",
issn = "0197-3681",
publisher = "Owens Clinic",
number = "2",

}

TY - JOUR

T1 - Neuropsychological dysfunction in HIV-infection

T2 - Characterization in a lymphadenopathy cohort

AU - Saykin, Andrew

AU - Janssen, R. S.

AU - Sprehn, G. C.

AU - Kaplan, J. E.

AU - Spira, T. J.

AU - Weller, P.

PY - 1988

Y1 - 1988

N2 - Comprehensive neuropsychological testing was administered to HIV seropositive gay men with lymphadenopathy syndrome (LAS). Nine of 18 LAS cases (50%) and 2 of 26 seronegative controls (8%) were abnormal by blind clinical rating (Fisher Exact Test, p=.003). Deficits were generally mild and in the areas of language (naming and fluency), attention, visual and auditory information processing, psychomotor speed and memory. These deficits, contrasted with relatively preserved higher level conceptual skills, are generally compatible with the pattern of impairment and predominately subcortical pathology described in AIDS dementia. There was a trend toward higher anxiety and depression scores in the abnormal cases, but neuropsychological dysfunction was not attributable to affective factors. Abnormal cases also had higher elevations on MMPI-168 measures of somatic complaints. Neuropsychological findings did not correlate with duration of LAS, absolute T helper values, or with MRI volumetric measures, indicating that psychometric testing may provide the first sign of CNS involvement in HIV infection.

AB - Comprehensive neuropsychological testing was administered to HIV seropositive gay men with lymphadenopathy syndrome (LAS). Nine of 18 LAS cases (50%) and 2 of 26 seronegative controls (8%) were abnormal by blind clinical rating (Fisher Exact Test, p=.003). Deficits were generally mild and in the areas of language (naming and fluency), attention, visual and auditory information processing, psychomotor speed and memory. These deficits, contrasted with relatively preserved higher level conceptual skills, are generally compatible with the pattern of impairment and predominately subcortical pathology described in AIDS dementia. There was a trend toward higher anxiety and depression scores in the abnormal cases, but neuropsychological dysfunction was not attributable to affective factors. Abnormal cases also had higher elevations on MMPI-168 measures of somatic complaints. Neuropsychological findings did not correlate with duration of LAS, absolute T helper values, or with MRI volumetric measures, indicating that psychometric testing may provide the first sign of CNS involvement in HIV infection.

UR - http://www.scopus.com/inward/record.url?scp=0023713459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023713459&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 81

EP - 95

JO - Clinical Neuropsychology

JF - Clinical Neuropsychology

SN - 0197-3681

IS - 2

ER -