Neuropsychological Function in Schizophrenia: Selective Impairment in Memory and Learning

Andrew Saykin, Ruben C. Gur, Raquel E. Gur, P. David Mozley, Lyn H. Mozley, Susan M. Resnick, D. Brian Kester, Paul Stafiniak

Research output: Contribution to journalArticle

1006 Citations (Scopus)

Abstract

• Unmedicated schizophrenic patients (according to DSM-III-R criteria) (n = 36) and age-matched normal controls (n = 36), balanced for parental socioeconomic status, were administered a battery of standardized neuropsychological tests. Patients showed generalized impairment relative to controls and a selective deficit in memory and learning compared with other functions. Selective impairment was not found on tests related to frontal system function (abstraction, verbal fluency, and motor). The observed pattern is consistent with greater involvement of the temporal-hippocampal system, against the background of diffuse dysfunction. Although impairment in memory and learning has been reported, the selectivity and relative severity compared with other behavioral functions have not been recognized. The specificity of this profile merits further examination. These findings lend support to the hypothesized importance of the temporal-hippocampal region in understanding the pathophysiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)618-624
Number of pages7
JournalArchives of General Psychiatry
Volume48
Issue number7
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Schizophrenia
Learning
Neuropsychological Tests
Memory Disorders
Temporal Lobe
Social Class
Diagnostic and Statistical Manual of Mental Disorders
Learning and Memory
Impairment
Socioeconomic Status
Merit
Verbal Fluency
Battery
Specificity
Standardized Tests

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Neuropsychological Function in Schizophrenia : Selective Impairment in Memory and Learning. / Saykin, Andrew; Gur, Ruben C.; Gur, Raquel E.; Mozley, P. David; Mozley, Lyn H.; Resnick, Susan M.; Kester, D. Brian; Stafiniak, Paul.

In: Archives of General Psychiatry, Vol. 48, No. 7, 1991, p. 618-624.

Research output: Contribution to journalArticle

Saykin, A, Gur, RC, Gur, RE, Mozley, PD, Mozley, LH, Resnick, SM, Kester, DB & Stafiniak, P 1991, 'Neuropsychological Function in Schizophrenia: Selective Impairment in Memory and Learning', Archives of General Psychiatry, vol. 48, no. 7, pp. 618-624. https://doi.org/10.1001/archpsyc.1991.01810310036007
Saykin, Andrew ; Gur, Ruben C. ; Gur, Raquel E. ; Mozley, P. David ; Mozley, Lyn H. ; Resnick, Susan M. ; Kester, D. Brian ; Stafiniak, Paul. / Neuropsychological Function in Schizophrenia : Selective Impairment in Memory and Learning. In: Archives of General Psychiatry. 1991 ; Vol. 48, No. 7. pp. 618-624.
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