Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine

Laura E. Halpin, Stuart A. Collins, Bryan Yamamoto

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Amphetamines are a class of psychostimulant drugs that are widely abused for their stimulant, euphoric, empathogenic and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotonin neurotransmission. Subsequent to these acute effects, methamphetamine and 3,4 methylenedioxymethamphetamine (MDMA) produce persistent damage to dopamine and serotonin nerve terminals. This review summarizes the numerous interdependent mechanisms including excitotoxicity, mitochondrial damage and oxidative stress that have been demonstrated to contribute to this damage. Emerging non-neuronal mechanisms by which the drugs may contribute to monoaminergic terminal damage, as well as the neuropsychiatric consequences of this terminal damage are also presented. Methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) have similar chemical structures and pharmacologic properties compared to other abused substances including cathinone (khat), as well as a relatively new class of novel synthetic amphetamines known as 'bath salts' that have gained popularity among drug abusers.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalLife Sciences
Volume97
Issue number1
DOIs
StatePublished - Feb 27 2014
Externally publishedYes

Fingerprint

Amphetamines
N-Methyl-3,4-methylenedioxyamphetamine
Methamphetamine
Dopamine
Serotonin
Catha
Drug Users
Baths
Synaptic Transmission
Pharmaceutical Preparations
Oxidative Stress
Oxidative stress
Salts
cathinone

Keywords

  • 3-4-Methylenedioxymethamphetamine
  • Excitotoxicity
  • Methamphetamine
  • Neurotoxicity
  • Oxidative stress
  • Psychosis

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine. / Halpin, Laura E.; Collins, Stuart A.; Yamamoto, Bryan.

In: Life Sciences, Vol. 97, No. 1, 27.02.2014, p. 37-44.

Research output: Contribution to journalReview article

Halpin, Laura E. ; Collins, Stuart A. ; Yamamoto, Bryan. / Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine. In: Life Sciences. 2014 ; Vol. 97, No. 1. pp. 37-44.
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