Neurotrophic and migratory properties of an olfactory ensheathing cell line

Alan V. Boruch, James J. Conners, Michelle Pipitone, Gail Deadwyler, Paul D. Storer, George H. Devries, Kathryn J. Jones

Research output: Contribution to journalArticlepeer-review

179 Scopus citations


Olfactory ensheathing cells (OECs) are a unique type of macroglia required for normal olfactory axonal regeneration throughout the lifetime of an individual. Recent evidence in the literature suggests that OECs transplanted into injured spinal cords may facilitate axonal regeneration. In this study, we evaluated the neurotrophic properties of OECs using a homogeneous clonal cell line (nOEC), which does not contain contaminating cell types found in all primary OEC cultures. The results indicate that nOECs express mRNA for NGF, BDNF, NT-4/5, and neuregulins, but not for NT-3 or CNTF. In addition, nOECs secrete NGF, BDNF, and neuregulin, but retain NT-4/5 intracellularly. Finally, prelabeled nOECs derived from rat survived transplantation into a dorsal hemisected region of the hamster spinal cord and migrated only in the injured, dorsal portion of the spinal cord. This migratory pattern suggests that the nOECs are viable in vivo and respond to signals originating from the injured neuronal cells and their processes.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
Issue number3
StatePublished - Mar 28 2001
Externally publishedYes


  • Ensheathing glia
  • Neurotrophins
  • Regeneration
  • Spinal cord injury
  • Xenograft

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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