Neurulation: Coming to closure

Jodi Smith, Gary C. Schoenwolf

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Neurulation is a morphogenetic event par excellence. During this highly choreographed four-dimensional process, a flat sheet of ectoderm is transformed into an elongated tubular rudiment, the neural tube, which exhibits rostro-caudal and mediolateral regionalization. Many tissues interact during neurulation to induce and regionalize the neuroectoderm and to produce the morphogenetic forces that drive neurulation. Such forces are generated by fundamental cell behaviors such as changes in cell shape, position and number. In addition, morphoregulatory molecules expressed during neurulation underlie induction and patterning of the forming neuraxis. Despite recent advances in our understanding of neurulation, neural tube defects continue to be a major health care concern. Further research, utilizing a panoply of approaches, is necessary to resolve this issue. Thus, although we are beginning to come to closure in terms of understanding the cellular and molecular mechanisms responsible for normal neural tube formation, 'coming to closure' is exactly the problem that requires resolution to prevent these devastating birth defects.

Original languageEnglish (US)
Pages (from-to)510-517
Number of pages8
JournalTrends in Neurosciences
Volume20
Issue number11
DOIs
StatePublished - Nov 1 1997
Externally publishedYes

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Neurulation
Neural Tube
Neural Plate
Ectoderm
Neural Tube Defects
Cell Shape
Cell Count
Delivery of Health Care
Research

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neurulation : Coming to closure. / Smith, Jodi; Schoenwolf, Gary C.

In: Trends in Neurosciences, Vol. 20, No. 11, 01.11.1997, p. 510-517.

Research output: Contribution to journalArticle

Smith, J & Schoenwolf, GC 1997, 'Neurulation: Coming to closure', Trends in Neurosciences, vol. 20, no. 11, pp. 510-517. https://doi.org/10.1016/S0166-2236(97)01121-1
Smith, Jodi ; Schoenwolf, Gary C. / Neurulation : Coming to closure. In: Trends in Neurosciences. 1997 ; Vol. 20, No. 11. pp. 510-517.
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