New and Recurrent Colorectal Cancers After Resection: a Systematic Review and Meta-analysis of Endoscopic Surveillance Studies

Lorenzo Fuccio, Douglas Rex, Thierry Ponchon, Leonardo Frazzoni, Mário Dinis-Ribeiro, Pradeep Bhandari, Evelien Dekker, Maria Pellisè, Loredana Correale, Jeanin van Hooft, Rodrigo Jover, Diogo Libanio, Franco Radaelli, Sergio Alfieri, Franco Bazzoli, Carlo Senore, Jaroslaw Regula, Thomas Seufferlein, Thomas Rösch, Prateek SharmaAlessandro Repici, Cesare Hassan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background & Aims: Outcomes of endoscopic surveillance after surgery for colorectal cancer (CRC) vary with the incidence and timing of CRC detection at anastomoses or non-anastomoses in the colorectum. We performed a systematic review and meta-analysis to evaluate the incidence of CRCs identified during surveillance colonoscopies of patients who have already undergone surgery for this cancer. Methods: We searched PubMed, EMBASE, SCOPUS, and the Cochrane Central Register of Clinical Trials through January 1, 2018 to identify studies investigating rates of CRCs at anastomoses or other locations in the colorectum after curative surgery for primary CRC. We collected data from published randomized controlled, prospective, and retrospective cohort studies. Data were analyzed by multivariate meta-analytic models. Results: From 2373 citations, we selected 27 studies with data on 15,803 index CRCs for analysis (89% of patients with stage I–III CRC). Overall, 296 CRCs at non-anastomotic locations were reported over time periods of more than 16 years (cumulative incidence, 2.2% of CRCs; 95% confidence interval [CI], 1.8%–2.9%). The risk of CRC at a non-anastomotic location was significantly reduced more than 36 months after resection compared with before this time point (odds ratio for non-anastomotic CRCs at 36–48 months vs 6–12 months after surgery, 0.61; 95% CI, 0.37–0.98; P =.031); 53.7% of all non-anastomotic CRCs were detected within 36 months of surgery. One hundred and fifty-eight CRCs were detected at anastomoses (cumulative incidence of 2.7%; 95% CI, 1.9%–3.9%). The risk of CRCs at anastomoses was significantly lower 24 months after resection than before (odds ratio for CRCs at anastomoses at 25–36 months after surgery vs 6–12 months, 0.56; 95% CI, 0.32–0.98; P =.036); 90.8% of all CRCs at anastomoses were detected within 36 months of surgery. Conclusions: After surgery for CRC, the highest risk of CRCs at anastomoses and at other locations in the colorectum is highest during 36 months after surgery—risk decreases thereafter. Patients who have undergone CRC resection should be evaluated by colonoscopy more closely during this time period. Longer intervals may be considered thereafter.

Original languageEnglish (US)
Pages (from-to)1309-1323.e3
JournalGastroenterology
Volume156
Issue number5
DOIs
StatePublished - Apr 1 2019

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Meta-Analysis
Colorectal Neoplasms
Confidence Intervals
Incidence
Colonoscopy
Odds Ratio
PubMed
Cohort Studies
Retrospective Studies
Clinical Trials
Neoplasms

Keywords

  • Colon Cancer
  • Early Detection
  • Endoscopy
  • Recurrence

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Fuccio, L., Rex, D., Ponchon, T., Frazzoni, L., Dinis-Ribeiro, M., Bhandari, P., ... Hassan, C. (2019). New and Recurrent Colorectal Cancers After Resection: a Systematic Review and Meta-analysis of Endoscopic Surveillance Studies. Gastroenterology, 156(5), 1309-1323.e3. https://doi.org/10.1053/j.gastro.2018.12.006

New and Recurrent Colorectal Cancers After Resection : a Systematic Review and Meta-analysis of Endoscopic Surveillance Studies. / Fuccio, Lorenzo; Rex, Douglas; Ponchon, Thierry; Frazzoni, Leonardo; Dinis-Ribeiro, Mário; Bhandari, Pradeep; Dekker, Evelien; Pellisè, Maria; Correale, Loredana; van Hooft, Jeanin; Jover, Rodrigo; Libanio, Diogo; Radaelli, Franco; Alfieri, Sergio; Bazzoli, Franco; Senore, Carlo; Regula, Jaroslaw; Seufferlein, Thomas; Rösch, Thomas; Sharma, Prateek; Repici, Alessandro; Hassan, Cesare.

In: Gastroenterology, Vol. 156, No. 5, 01.04.2019, p. 1309-1323.e3.

Research output: Contribution to journalArticle

Fuccio, L, Rex, D, Ponchon, T, Frazzoni, L, Dinis-Ribeiro, M, Bhandari, P, Dekker, E, Pellisè, M, Correale, L, van Hooft, J, Jover, R, Libanio, D, Radaelli, F, Alfieri, S, Bazzoli, F, Senore, C, Regula, J, Seufferlein, T, Rösch, T, Sharma, P, Repici, A & Hassan, C 2019, 'New and Recurrent Colorectal Cancers After Resection: a Systematic Review and Meta-analysis of Endoscopic Surveillance Studies', Gastroenterology, vol. 156, no. 5, pp. 1309-1323.e3. https://doi.org/10.1053/j.gastro.2018.12.006
Fuccio, Lorenzo ; Rex, Douglas ; Ponchon, Thierry ; Frazzoni, Leonardo ; Dinis-Ribeiro, Mário ; Bhandari, Pradeep ; Dekker, Evelien ; Pellisè, Maria ; Correale, Loredana ; van Hooft, Jeanin ; Jover, Rodrigo ; Libanio, Diogo ; Radaelli, Franco ; Alfieri, Sergio ; Bazzoli, Franco ; Senore, Carlo ; Regula, Jaroslaw ; Seufferlein, Thomas ; Rösch, Thomas ; Sharma, Prateek ; Repici, Alessandro ; Hassan, Cesare. / New and Recurrent Colorectal Cancers After Resection : a Systematic Review and Meta-analysis of Endoscopic Surveillance Studies. In: Gastroenterology. 2019 ; Vol. 156, No. 5. pp. 1309-1323.e3.
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abstract = "Background & Aims: Outcomes of endoscopic surveillance after surgery for colorectal cancer (CRC) vary with the incidence and timing of CRC detection at anastomoses or non-anastomoses in the colorectum. We performed a systematic review and meta-analysis to evaluate the incidence of CRCs identified during surveillance colonoscopies of patients who have already undergone surgery for this cancer. Methods: We searched PubMed, EMBASE, SCOPUS, and the Cochrane Central Register of Clinical Trials through January 1, 2018 to identify studies investigating rates of CRCs at anastomoses or other locations in the colorectum after curative surgery for primary CRC. We collected data from published randomized controlled, prospective, and retrospective cohort studies. Data were analyzed by multivariate meta-analytic models. Results: From 2373 citations, we selected 27 studies with data on 15,803 index CRCs for analysis (89{\%} of patients with stage I–III CRC). Overall, 296 CRCs at non-anastomotic locations were reported over time periods of more than 16 years (cumulative incidence, 2.2{\%} of CRCs; 95{\%} confidence interval [CI], 1.8{\%}–2.9{\%}). The risk of CRC at a non-anastomotic location was significantly reduced more than 36 months after resection compared with before this time point (odds ratio for non-anastomotic CRCs at 36–48 months vs 6–12 months after surgery, 0.61; 95{\%} CI, 0.37–0.98; P =.031); 53.7{\%} of all non-anastomotic CRCs were detected within 36 months of surgery. One hundred and fifty-eight CRCs were detected at anastomoses (cumulative incidence of 2.7{\%}; 95{\%} CI, 1.9{\%}–3.9{\%}). The risk of CRCs at anastomoses was significantly lower 24 months after resection than before (odds ratio for CRCs at anastomoses at 25–36 months after surgery vs 6–12 months, 0.56; 95{\%} CI, 0.32–0.98; P =.036); 90.8{\%} of all CRCs at anastomoses were detected within 36 months of surgery. Conclusions: After surgery for CRC, the highest risk of CRCs at anastomoses and at other locations in the colorectum is highest during 36 months after surgery—risk decreases thereafter. Patients who have undergone CRC resection should be evaluated by colonoscopy more closely during this time period. Longer intervals may be considered thereafter.",
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TY - JOUR

T1 - New and Recurrent Colorectal Cancers After Resection

T2 - a Systematic Review and Meta-analysis of Endoscopic Surveillance Studies

AU - Fuccio, Lorenzo

AU - Rex, Douglas

AU - Ponchon, Thierry

AU - Frazzoni, Leonardo

AU - Dinis-Ribeiro, Mário

AU - Bhandari, Pradeep

AU - Dekker, Evelien

AU - Pellisè, Maria

AU - Correale, Loredana

AU - van Hooft, Jeanin

AU - Jover, Rodrigo

AU - Libanio, Diogo

AU - Radaelli, Franco

AU - Alfieri, Sergio

AU - Bazzoli, Franco

AU - Senore, Carlo

AU - Regula, Jaroslaw

AU - Seufferlein, Thomas

AU - Rösch, Thomas

AU - Sharma, Prateek

AU - Repici, Alessandro

AU - Hassan, Cesare

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background & Aims: Outcomes of endoscopic surveillance after surgery for colorectal cancer (CRC) vary with the incidence and timing of CRC detection at anastomoses or non-anastomoses in the colorectum. We performed a systematic review and meta-analysis to evaluate the incidence of CRCs identified during surveillance colonoscopies of patients who have already undergone surgery for this cancer. Methods: We searched PubMed, EMBASE, SCOPUS, and the Cochrane Central Register of Clinical Trials through January 1, 2018 to identify studies investigating rates of CRCs at anastomoses or other locations in the colorectum after curative surgery for primary CRC. We collected data from published randomized controlled, prospective, and retrospective cohort studies. Data were analyzed by multivariate meta-analytic models. Results: From 2373 citations, we selected 27 studies with data on 15,803 index CRCs for analysis (89% of patients with stage I–III CRC). Overall, 296 CRCs at non-anastomotic locations were reported over time periods of more than 16 years (cumulative incidence, 2.2% of CRCs; 95% confidence interval [CI], 1.8%–2.9%). The risk of CRC at a non-anastomotic location was significantly reduced more than 36 months after resection compared with before this time point (odds ratio for non-anastomotic CRCs at 36–48 months vs 6–12 months after surgery, 0.61; 95% CI, 0.37–0.98; P =.031); 53.7% of all non-anastomotic CRCs were detected within 36 months of surgery. One hundred and fifty-eight CRCs were detected at anastomoses (cumulative incidence of 2.7%; 95% CI, 1.9%–3.9%). The risk of CRCs at anastomoses was significantly lower 24 months after resection than before (odds ratio for CRCs at anastomoses at 25–36 months after surgery vs 6–12 months, 0.56; 95% CI, 0.32–0.98; P =.036); 90.8% of all CRCs at anastomoses were detected within 36 months of surgery. Conclusions: After surgery for CRC, the highest risk of CRCs at anastomoses and at other locations in the colorectum is highest during 36 months after surgery—risk decreases thereafter. Patients who have undergone CRC resection should be evaluated by colonoscopy more closely during this time period. Longer intervals may be considered thereafter.

AB - Background & Aims: Outcomes of endoscopic surveillance after surgery for colorectal cancer (CRC) vary with the incidence and timing of CRC detection at anastomoses or non-anastomoses in the colorectum. We performed a systematic review and meta-analysis to evaluate the incidence of CRCs identified during surveillance colonoscopies of patients who have already undergone surgery for this cancer. Methods: We searched PubMed, EMBASE, SCOPUS, and the Cochrane Central Register of Clinical Trials through January 1, 2018 to identify studies investigating rates of CRCs at anastomoses or other locations in the colorectum after curative surgery for primary CRC. We collected data from published randomized controlled, prospective, and retrospective cohort studies. Data were analyzed by multivariate meta-analytic models. Results: From 2373 citations, we selected 27 studies with data on 15,803 index CRCs for analysis (89% of patients with stage I–III CRC). Overall, 296 CRCs at non-anastomotic locations were reported over time periods of more than 16 years (cumulative incidence, 2.2% of CRCs; 95% confidence interval [CI], 1.8%–2.9%). The risk of CRC at a non-anastomotic location was significantly reduced more than 36 months after resection compared with before this time point (odds ratio for non-anastomotic CRCs at 36–48 months vs 6–12 months after surgery, 0.61; 95% CI, 0.37–0.98; P =.031); 53.7% of all non-anastomotic CRCs were detected within 36 months of surgery. One hundred and fifty-eight CRCs were detected at anastomoses (cumulative incidence of 2.7%; 95% CI, 1.9%–3.9%). The risk of CRCs at anastomoses was significantly lower 24 months after resection than before (odds ratio for CRCs at anastomoses at 25–36 months after surgery vs 6–12 months, 0.56; 95% CI, 0.32–0.98; P =.036); 90.8% of all CRCs at anastomoses were detected within 36 months of surgery. Conclusions: After surgery for CRC, the highest risk of CRCs at anastomoses and at other locations in the colorectum is highest during 36 months after surgery—risk decreases thereafter. Patients who have undergone CRC resection should be evaluated by colonoscopy more closely during this time period. Longer intervals may be considered thereafter.

KW - Colon Cancer

KW - Early Detection

KW - Endoscopy

KW - Recurrence

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