New Approaches for Improving Engraftment after Cord Blood Transplantation

Vanderson Rocha, Hal Broxymeyer

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Use of unrelated umbilical cord blood cells (UCB) as an alternative source of hematopoietic cell transplantation (HCT) has been widely used mainly for patients lacking an HLA-matched donor. There are many advantages for using cord blood cells over bone marrow or mobilized peripheral blood (MBP) from volunteer donors, such as rapid availability, absence of risk for the donor, decreased incidence of acute graft-versus-host disease (aGVHD). However, a significant clinical problem is delayed engraftment, which is directly correlated with the number of hematopoietic stem cells (HSC) in a cord blood unit. The understanding of methods to improve collection, expansion, and homing of cord blood cells, the identification of prognostic factors associated with engraftment that can be easily modified (eg, strategies for donor choice), and development of new approaches including use of multiple donors, cotransplantation with accessory cells are of crucial importance to circumvent the problem of delayed engraftment after UCB transplantation. Those approaches may greatly increase the quality and availability of cord blood for transplantation.

Original languageEnglish (US)
Pages (from-to)S126-S132
JournalBiology of Blood and Marrow Transplantation
Volume16
Issue number1
DOIs
StatePublished - Jan 2010

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Keywords

  • Double cord blood transplantation
  • Engraftment
  • Expansion
  • Homing
  • Umbilical cord blood transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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