New approaches to antiarrhythmic therapy: Emerging therapeutic applications of the cell biology of cardiac arrhythmias

E. Carmeliet, H. A. Fozzard, M. Hiraoka, M. J. Janse, S. Ogawa, D. M. Roden, M. R. Rosen, Y. Rudy, P. J. Schwartz, P. S. Matteo, J. A. Camm, C. Antzelevitch, P. A. Boyden, W. A. Catterall, G. I. Fishman, A. L. George, S. Izumo, J. Jalife, C. T. January, A. G. KléberE. Marban, A. R. Marks, P. M. Spooner, A. L. Waldo, J. M. Weiss, D. P. Zipes

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Cardiac arrhythmias complicate many diseases affecting the heart and the circulation, and incorporate a multiplicity of underlying mechanisms. The evolution of scientific knowledge has made the complex changes produced by cardiovascular disease sufficiently understood at the organ, cellular, and molecular levels such that there is a diversity of therapeutic targets for pharmacological therapy and/or prevention. Moreover, the approach of rational drug design in mechanism-specific and disease-specific fashion facilitates targeting of therapy via the methods of molecular, structural and translational biology. Additional approaches, employing similar drug design strategies but based on gene therapy and transcriptional and translational modification are on the horizon. Hence, there is reason to be optimistic regarding the design, testing and clinical availability of novel antiarrhythmic therapies. Condensed Abstract: The evolution of scientific knowledge has made the effects of cardiovascular disease sufficiently understood at the organ, cellular, and molecular levels such that there is a diversity of therapeutic targets for pharmacological therapy and/or prevention. Moreover, the approach of rational drug design facilitates targeting of therapy via the methods of molecular, structural and translational biology. Additional approaches, employing similar drug design strategies but based on gene therapy and transcriptional and translational modification are on the horizon. Hence, there is reason to be optimistic regarding the design, testing and clinical availability of novel antiarrhythmic therapies.

Original languageEnglish (US)
Pages (from-to)345-360
Number of pages16
JournalCardiovascular research
Volume52
Issue number3
DOIs
StatePublished - Dec 31 2001

Keywords

  • Antiarrhythmic agents
  • Gene therapy
  • Genes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Carmeliet, E., Fozzard, H. A., Hiraoka, M., Janse, M. J., Ogawa, S., Roden, D. M., Rosen, M. R., Rudy, Y., Schwartz, P. J., Matteo, P. S., Camm, J. A., Antzelevitch, C., Boyden, P. A., Catterall, W. A., Fishman, G. I., George, A. L., Izumo, S., Jalife, J., January, C. T., ... Zipes, D. P. (2001). New approaches to antiarrhythmic therapy: Emerging therapeutic applications of the cell biology of cardiac arrhythmias. Cardiovascular research, 52(3), 345-360. https://doi.org/10.1016/S0008-6363(01)00465-5