New Concepts in Atrial Fibrillation: Mechanism and Remodeling

Chung Chuan Chou, Peng-Sheng Chen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Atrial fibrillation (AF) is a complex disease with many possible mechanisms. Studies indicate that the arrhythmogenic foci within the thoracic veins are AF initiators. Once initiated, AF alters atrial electrical and structural properties in a way that promotes its own maintenance and recurrences and may alter the response to antiarrhythmic drugs. The exact mechanisms by which the initiators trigger AF remain elusive, however. Evidence to date suggests that autonomic modulation does have an adjunctive role to play in catheter AF ablation, especially when applied selectively. Further mechanistic and clinical studies are warranted before a wider application can be recommended.

Original languageEnglish
Pages (from-to)53-63
Number of pages11
JournalMedical Clinics of North America
Volume92
Issue number1
DOIs
StatePublished - Jan 2008

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Atrial Remodeling
Atrial Fibrillation
Anti-Arrhythmia Agents
Veins
Thorax
Catheters
Maintenance
Recurrence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

New Concepts in Atrial Fibrillation : Mechanism and Remodeling. / Chou, Chung Chuan; Chen, Peng-Sheng.

In: Medical Clinics of North America, Vol. 92, No. 1, 01.2008, p. 53-63.

Research output: Contribution to journalArticle

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