New Concepts in Atrial Fibrillation: Neural Mechanisms and Calcium Dynamics

Chung Chuan Chou, Peng-Sheng Chen

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Atrial fibrillation (AF) is a complex arrhythmia with multiple possible mechanisms. It requires a trigger for initiation and a favorable substrate for maintenance. Pulmonary vein myocardial sleeves have the potential to generate spontaneous activity, and this arrhythmogenic activity is surfaced by modulation of intracellular calcium dynamics. Direct autonomic nerve recordings in canine models show that simultaneous sympathovagal discharges are the most common triggers of paroxysmal atrial tachycardia and paroxysmal AF. Autonomic modulation as a potential therapeutic strategy has been targeted clinically and experimentally, but its effectiveness as an adjunctive therapeutic modality to catheter ablation of AF has been inconsistent. Further studies are warranted before application can be widely implied for therapies of clinical AF.

Original languageEnglish
Pages (from-to)35-43
Number of pages9
JournalCardiology Clinics
Volume27
Issue number1
DOIs
StatePublished - Feb 2009

Fingerprint

Atrial Fibrillation
Calcium
Paroxysmal Tachycardia
Autonomic Pathways
Catheter Ablation
Pulmonary Veins
Canidae
Cardiac Arrhythmias
Therapeutics
Maintenance

Keywords

  • Atrium
  • Autonomic
  • Calcium
  • Fibrillation
  • Nervous system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

New Concepts in Atrial Fibrillation : Neural Mechanisms and Calcium Dynamics. / Chou, Chung Chuan; Chen, Peng-Sheng.

In: Cardiology Clinics, Vol. 27, No. 1, 02.2009, p. 35-43.

Research output: Contribution to journalArticle

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