New Concepts in Atrial Fibrillation: Neural Mechanisms and Calcium Dynamics

Chung Chuan Chou, Peng Sheng Chen

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Atrial fibrillation (AF) is a complex arrhythmia with multiple possible mechanisms. It requires a trigger for initiation and a favorable substrate for maintenance. Pulmonary vein myocardial sleeves have the potential to generate spontaneous activity, and this arrhythmogenic activity is surfaced by modulation of intracellular calcium dynamics. Direct autonomic nerve recordings in canine models show that simultaneous sympathovagal discharges are the most common triggers of paroxysmal atrial tachycardia and paroxysmal AF. Autonomic modulation as a potential therapeutic strategy has been targeted clinically and experimentally, but its effectiveness as an adjunctive therapeutic modality to catheter ablation of AF has been inconsistent. Further studies are warranted before application can be widely implied for therapies of clinical AF.

Original languageEnglish (US)
Pages (from-to)35-43
Number of pages9
JournalCardiology clinics
Issue number1
StatePublished - Feb 2009


  • Atrium
  • Autonomic
  • Calcium
  • Fibrillation
  • Nervous system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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