New insights in antigen processing and epitope selection: Development of novel immunotherapeutic stragies for cancer, autoimmunity and infectious diseases

Azizul Haque, J. S. Blum

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Current evidence suggests that MHC class II-restricted CD4+ T-cells play a crucial role in orchestrating host immune responses against cancer as well as autoimmune and infectious diseases. Antigens must be processed within endosomal and lysosomal compartments of antigen presenting cells (APC) before binding to MHC class II molecules for display to T-cells. Only a limited number of processed peptides termed immunodominant are selected for display by MHC class II molecules and prove capable of inducing strong T-cell responses. Thus processing reactions within APC are of central importance for the development of effective vaccines as they modulate the number of peptide: class II complexes by enhancing or disrupting epitope formation and display. Studies suggest that there are substantial gaps in our knowledge of how antigen processing and presentation by APC regulates epitope selection and immunodominance in disease situations. Here we describe new insights in antigen processing and epitope selection with relevance to immunotherapeutic strategies for cancer, autoimmunity and infectious diseases.

Original languageEnglish (US)
Pages (from-to)93-104
Number of pages12
JournalJournal of biological regulators and homeostatic agents
Volume19
Issue number3-4
StatePublished - Jul 1 2005

Keywords

  • Antigen presenting cells
  • Antigen processing and presentation
  • Autoimmunity
  • Cancer
  • Epitope selection
  • Infectious diseases
  • Lysosomal reductase GILT
  • MHC class II

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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