New insights into the pathophysiology of ischemic heart disease

C. J. Pepine, J. F. Lewis, M. C. Limacher, C. R. Conti, M. B. Grant, T. J. Wargovich, J. L. Mehta, E. Handberg

Research output: Contribution to journalReview article


Recent insights into the processes contributing to coronary artery disease (CAD) suggest new targets For diagnosis and therapeutic intervention. in particular, we now have a better understanding of the important roles that factors generated by the endothelium play in mediating vasoconstriction, thrombosis, smooth muscle cell (SMC) growth, and leukocyte recruitment. Many CAD risk factors, such as cigarette smoking, hypertension, and hypercholesterolemia, that can injure the endothelium and disrupt these important functions, are especially prevalent in women. Evidence suggests that the prominent vascular protective actions of estrogen may stem from (1) effects on endothelium, nitric oxide (NO), and oxidative metabolism; (2) a direct vasodilatory action on the arterial wall; (3) effects on the balance between endogenous Fibrinolysis and thrombosis; and/or (4) favorable alterations of lipid metabolism.

Original languageEnglish (US)
Pages (from-to)236-242
Number of pages7
JournalJournal of Myocardial Ischemia
Issue number6
StatePublished - Dec 1 1995


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pepine, C. J., Lewis, J. F., Limacher, M. C., Conti, C. R., Grant, M. B., Wargovich, T. J., Mehta, J. L., & Handberg, E. (1995). New insights into the pathophysiology of ischemic heart disease. Journal of Myocardial Ischemia, 7(6), 236-242.