New treatment strategies for bacterial meningitis

Research output: Contribution to journalReview article

4 Scopus citations


Over the last several years, the therapeutic approach to bacterial meningitis has been changing. The neurological complications of bacterial meningitis result from an inflammatory process that is initiated by the lysis of bacteria in the subarachnoid space by antibiotics; to alter the pathophysiologic events initiated by this lysis, adjunctive therapy to antimicrobial therapy has been investigated in experimental and clinical trials. This article reviews our present understanding of bacterial meningitis, the efficacy of dexamethasone in treatment, and the potential use of leukocyte monoclonal antibodies, pentoxifylline, nonsteroidal antiinflammatory agents, and anticytokine antibodies.

Original languageEnglish (US)
Pages (from-to)373-386
Number of pages14
JournalClinical neuropharmacology
Issue number5
StatePublished - Jan 1 1993
Externally publishedYes


  • Anticytokine antibodies
  • Bacterial meningitis
  • Dexamethasone
  • Leukocyte monoclonal antibodies
  • Nonsteroidal antiinflammatory agents
  • Pentoxifylline

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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