NFκB activation, TNF-α expression, and apoptosis in the AIDS-Dementia-Complex

K. Rostasy, L. Monti, C. Yiannoutsos, J. Wu, J. Bell, J. Hedreen, B. A. Navia

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The role of NFκB activation and its relationship to inflammatory mediators and apoptosis in the HIV-infected brain have remained uncertain. The cellular and regional distribution of NFκB, TNF-α, and apoptosis was examined in the frontal cortex (FC), deep white matter (DWM) and the basal ganglia (BG) of 17 patients with ADC. Nuclear staining for NFκB was localized predominantly to perivascular microglia/macrophages in the BG and DWM and correlated with ADC severity. Correlations were further found with HLA-DR, iNOS, TNF-α, and gp41 expression in these regions. The number of TUNEL-positive cells, particularly in the BG, correlated with ADC stage. Logistic regression analysis further showed a significant relationship between the likelihood of TUNEL staining in the BG and worsening cognitive impairment.

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalJournal of NeuroVirology
Volume6
Issue number6
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • AIDS-Dementia-Complex
  • Apoptosis
  • NFκB
  • TNF-α

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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