NFκB activation, TNF-α expression, and apoptosis in the AIDS-Dementia-Complex

K. Rostasy, L. Monti, Constantin Yiannoutsos, J. Wu, J. Bell, J. Hedreen, B. A. Navia

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The role of NFκB activation and its relationship to inflammatory mediators and apoptosis in the HIV-infected brain have remained uncertain. The cellular and regional distribution of NFκB, TNF-α, and apoptosis was examined in the frontal cortex (FC), deep white matter (DWM) and the basal ganglia (BG) of 17 patients with ADC. Nuclear staining for NFκB was localized predominantly to perivascular microglia/macrophages in the BG and DWM and correlated with ADC severity. Correlations were further found with HLA-DR, iNOS, TNF-α, and gp41 expression in these regions. The number of TUNEL-positive cells, particularly in the BG, correlated with ADC stage. Logistic regression analysis further showed a significant relationship between the likelihood of TUNEL staining in the BG and worsening cognitive impairment.

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalJournal of NeuroVirology
Volume6
Issue number6
StatePublished - 2000
Externally publishedYes

Fingerprint

AIDS Dementia Complex
Basal Ganglia
Apoptosis
In Situ Nick-End Labeling
Staining and Labeling
Microglia
Frontal Lobe
HLA-DR Antigens
Logistic Models
Macrophages
Regression Analysis
HIV
Brain
White Matter

Keywords

  • AIDS-Dementia-Complex
  • Apoptosis
  • NFκB
  • TNF-α

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Rostasy, K., Monti, L., Yiannoutsos, C., Wu, J., Bell, J., Hedreen, J., & Navia, B. A. (2000). NFκB activation, TNF-α expression, and apoptosis in the AIDS-Dementia-Complex. Journal of NeuroVirology, 6(6), 537-543.

NFκB activation, TNF-α expression, and apoptosis in the AIDS-Dementia-Complex. / Rostasy, K.; Monti, L.; Yiannoutsos, Constantin; Wu, J.; Bell, J.; Hedreen, J.; Navia, B. A.

In: Journal of NeuroVirology, Vol. 6, No. 6, 2000, p. 537-543.

Research output: Contribution to journalArticle

Rostasy, K, Monti, L, Yiannoutsos, C, Wu, J, Bell, J, Hedreen, J & Navia, BA 2000, 'NFκB activation, TNF-α expression, and apoptosis in the AIDS-Dementia-Complex', Journal of NeuroVirology, vol. 6, no. 6, pp. 537-543.
Rostasy, K. ; Monti, L. ; Yiannoutsos, Constantin ; Wu, J. ; Bell, J. ; Hedreen, J. ; Navia, B. A. / NFκB activation, TNF-α expression, and apoptosis in the AIDS-Dementia-Complex. In: Journal of NeuroVirology. 2000 ; Vol. 6, No. 6. pp. 537-543.
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