NF-κB: Its role in colorectal cancer

A. Hartley, H. Wei, L. Prabhu, M. Martin, Tao Lu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Colorectal cancer (CRC) is a major worldwide health problem and is the second leading cause of cancer-related deaths in the United States. Despite considerable progress in diagnosis and treatment, a high mortality rate persists, largely due to the complications associated with metastatic incidences. The pro-inflammatory transcription factor nuclear factor κB (NF-κB) is a central player in inflammatory responses and tumor progression. In CRC, constitutively activated NF-κB has been observed in the majority of patients. NF-κB significantly affects the process of tumorigenesis by promoting many aspects including tumor growth, proliferation, invasiveness, and angiogenesis. Importantly, the critical contribution of NF-κB to inflammation and tumorigenesis is due to its control of the expression of a large variety of target genes, many of which, when aberrantly expressed, help to orchestrate and promote CRC malignant potential. These NF-κB target genes include those vital to cell cycle regulation, cell proliferation, metastasis, and cell survival. Additionally, activation of NF-κB in both cancerous cells and inflammatory cells and subsequent induction of cytokines/chemokines within the tumor microenvironment also contribute to CRC cell malignancy in both autocrine and paracrine manners. These evidences implicate inhibition of NF-κB as an important approach for CRC therapy. Several recent combinatorial approaches using classical chemotherapeutics with NF-κB inhibitors seem to have resulted in very promising outcomes.

Original languageEnglish (US)
Title of host publicationRole of Transcription Factors in Gastrointestinal Malignancies
PublisherSpringer Singapore
Pages247-260
Number of pages14
ISBN (Electronic)9789811067280
ISBN (Print)9789811067273
DOIs
StatePublished - Jan 1 2018

Fingerprint

Tumors
Colorectal Neoplasms
Genes
Cells
Cell proliferation
Medical problems
Neoplasms
Chemokines
Carcinogenesis
Transcription Factors
Chemical activation
Tumor Microenvironment
Cytokines
Cell Survival
Cell Cycle
Cell Proliferation
Neoplasm Metastasis
Inflammation
Mortality
Incidence

Keywords

  • Colorectal cancer
  • NF-κB
  • Transcription factor

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hartley, A., Wei, H., Prabhu, L., Martin, M., & Lu, T. (2018). NF-κB: Its role in colorectal cancer. In Role of Transcription Factors in Gastrointestinal Malignancies (pp. 247-260). Springer Singapore. https://doi.org/10.1007/978-981-10-6728-0_17

NF-κB : Its role in colorectal cancer. / Hartley, A.; Wei, H.; Prabhu, L.; Martin, M.; Lu, Tao.

Role of Transcription Factors in Gastrointestinal Malignancies. Springer Singapore, 2018. p. 247-260.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hartley, A, Wei, H, Prabhu, L, Martin, M & Lu, T 2018, NF-κB: Its role in colorectal cancer. in Role of Transcription Factors in Gastrointestinal Malignancies. Springer Singapore, pp. 247-260. https://doi.org/10.1007/978-981-10-6728-0_17
Hartley A, Wei H, Prabhu L, Martin M, Lu T. NF-κB: Its role in colorectal cancer. In Role of Transcription Factors in Gastrointestinal Malignancies. Springer Singapore. 2018. p. 247-260 https://doi.org/10.1007/978-981-10-6728-0_17
Hartley, A. ; Wei, H. ; Prabhu, L. ; Martin, M. ; Lu, Tao. / NF-κB : Its role in colorectal cancer. Role of Transcription Factors in Gastrointestinal Malignancies. Springer Singapore, 2018. pp. 247-260
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