NF-κB: Its role in colorectal cancer

A. Hartley, H. Wei, L. Prabhu, M. Martin, Tao Lu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Colorectal cancer (CRC) is a major worldwide health problem and is the second leading cause of cancer-related deaths in the United States. Despite considerable progress in diagnosis and treatment, a high mortality rate persists, largely due to the complications associated with metastatic incidences. The pro-inflammatory transcription factor nuclear factor κB (NF-κB) is a central player in inflammatory responses and tumor progression. In CRC, constitutively activated NF-κB has been observed in the majority of patients. NF-κB significantly affects the process of tumorigenesis by promoting many aspects including tumor growth, proliferation, invasiveness, and angiogenesis. Importantly, the critical contribution of NF-κB to inflammation and tumorigenesis is due to its control of the expression of a large variety of target genes, many of which, when aberrantly expressed, help to orchestrate and promote CRC malignant potential. These NF-κB target genes include those vital to cell cycle regulation, cell proliferation, metastasis, and cell survival. Additionally, activation of NF-κB in both cancerous cells and inflammatory cells and subsequent induction of cytokines/chemokines within the tumor microenvironment also contribute to CRC cell malignancy in both autocrine and paracrine manners. These evidences implicate inhibition of NF-κB as an important approach for CRC therapy. Several recent combinatorial approaches using classical chemotherapeutics with NF-κB inhibitors seem to have resulted in very promising outcomes.

Original languageEnglish (US)
Title of host publicationRole of Transcription Factors in Gastrointestinal Malignancies
PublisherSpringer Singapore
Pages247-260
Number of pages14
ISBN (Electronic)9789811067280
ISBN (Print)9789811067273
DOIs
StatePublished - Jan 1 2018

Keywords

  • Colorectal cancer
  • NF-κB
  • Transcription factor

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Hartley, A., Wei, H., Prabhu, L., Martin, M., & Lu, T. (2018). NF-κB: Its role in colorectal cancer. In Role of Transcription Factors in Gastrointestinal Malignancies (pp. 247-260). Springer Singapore. https://doi.org/10.1007/978-981-10-6728-0_17