NF-κB mediates IL-1β-induced synthesis/release of α2-macroglobulin in a human glial cell line

Feng Gao, Kelly R. Bales, Richard C. Dodel, Junyi Liu, Xianming Chen, Harald Hample, Martin Farlow, Steven M. Paul, Yansheng Du

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Increasingly, inflammatory responses in localized areas of brain parenchyma in response to the extracellular deposition of the Aβ peptides are thought to play a causative role in Alzheimer's disease (AD) progression. Anti-inflammatory agents, in particular non-steroid anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, have been shown to be associated with a delayed onset or slowed rate of disease progression in several epidemiological studies. Activation of glial cells and the subsequent expression of a number of proteins including α2-macroglobulin (α2M) are associated with the induction of brain tissue inflammation. Additionally cytokines, such as interleukin-1α (IL-1α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) are co-localized to senile plaques, a neuropathological hallmark of AD. α2M binds various cytokines, including IL-1β, as well as Aβ. In this study, we demonstrate that IL-1β induces α2M synthesis/release from a human astroglial cell line (U373) via the activation of the nuclear transcription factor NF-κB. Our data suggest that attenuation of IL-1β-induced α2M synthesis/release by blocking NF-κB activation may potentially be 'protective' against the development of late-onset AD.

Original languageEnglish
Pages (from-to)108-114
Number of pages7
JournalMolecular Brain Research
Volume105
Issue number1-2
DOIs
StatePublished - Sep 30 2002

Fingerprint

Macroglobulins
Interleukin-1
Neuroglia
Cell Line
Alzheimer Disease
Disease Progression
Anti-Inflammatory Agents
Cytokines
Ibuprofen
Amyloid Plaques
Encephalitis
Aspirin
Epidemiologic Studies
Interleukin-6
Transcription Factors
Peptides
Brain
Pharmaceutical Preparations
Proteins

Keywords

  • α-Macroglobulin (αM)
  • Alzheimer's disease (AD)
  • Interleukin-1β (IL-1β)
  • NF-κB

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

NF-κB mediates IL-1β-induced synthesis/release of α2-macroglobulin in a human glial cell line. / Gao, Feng; Bales, Kelly R.; Dodel, Richard C.; Liu, Junyi; Chen, Xianming; Hample, Harald; Farlow, Martin; Paul, Steven M.; Du, Yansheng.

In: Molecular Brain Research, Vol. 105, No. 1-2, 30.09.2002, p. 108-114.

Research output: Contribution to journalArticle

Gao, Feng ; Bales, Kelly R. ; Dodel, Richard C. ; Liu, Junyi ; Chen, Xianming ; Hample, Harald ; Farlow, Martin ; Paul, Steven M. ; Du, Yansheng. / NF-κB mediates IL-1β-induced synthesis/release of α2-macroglobulin in a human glial cell line. In: Molecular Brain Research. 2002 ; Vol. 105, No. 1-2. pp. 108-114.
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