Nicotinamide and the regulation of renal phosphate transport.

S. A. Kempson, J. A. McAteer, K. I. Wu, R. A. Bacon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The specific inhibitory action of nicotinamide on renal Pi transport does not require de novo protein synthesis and can be detected within 1 hr, at least in low Pi diet rats. These properties characterize nicotinamide as a rapidly acting regulator of the Pi transport system in the renal BBM (Kempson and Dousa, 1986). The studies with LLC-PK 1 cells strongly suggest that the action of nicotinamide in rats is due to a direct effect on the cells of the proximal tubule. Further studies on the mechanism of action of nicotinamide may lead to an understanding of the intracellular mechanisms that mediate the action of rapidly acting physiological regulators of BBM transport of Pi.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalProgress in Clinical and Biological Research
Volume258
StatePublished - 1988

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Niacinamide
Phosphates
Kidney
Diet
Proteins

ASJC Scopus subject areas

  • Medicine(all)

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Kempson, S. A., McAteer, J. A., Wu, K. I., & Bacon, R. A. (1988). Nicotinamide and the regulation of renal phosphate transport. Progress in Clinical and Biological Research, 258, 185-193.

Nicotinamide and the regulation of renal phosphate transport. / Kempson, S. A.; McAteer, J. A.; Wu, K. I.; Bacon, R. A.

In: Progress in Clinical and Biological Research, Vol. 258, 1988, p. 185-193.

Research output: Contribution to journalArticle

Kempson, SA, McAteer, JA, Wu, KI & Bacon, RA 1988, 'Nicotinamide and the regulation of renal phosphate transport.', Progress in Clinical and Biological Research, vol. 258, pp. 185-193.
Kempson, S. A. ; McAteer, J. A. ; Wu, K. I. ; Bacon, R. A. / Nicotinamide and the regulation of renal phosphate transport. In: Progress in Clinical and Biological Research. 1988 ; Vol. 258. pp. 185-193.
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