Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample

Jill Hardin, Yungang He, Harold S. Javitz, Jennifer Wessel, Ruth E. Krasnow, Elizabeth Tildesley, Hyman Hops, Gary E. Swan, Andrew W. Bergen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Nicotine withdrawal symptoms are related to smoking cessation. A Rasch model has been used to develop a unidimensional sensitivity score representing multiple correlated measures of nicotine withdrawal. A previous autosome-wide screen identified a nonparametric linkage (NPL) log-likelihood ratio (LOD) score of 2.7 on chromosome 6q26 for the sum of nine withdrawal symptoms. Methods: The objectives of these analyses were to (a) assess the influence of nicotine withdrawal sensitivity on relapse, (b) conduct autosome-wide NPL analysis of nicotine withdrawal sensitivity among 158 pedigrees with 432 individuals with microsatellite genotypes and nicotine withdrawal scores, and (c) explore familybased association of single nucleotide polymorphism (SNP) at the mu opioid receptor candidate gene (OPRM1) with nicotine withdrawal sensitivity in 172 nuclear pedigrees with 419 individuals with both SNP genotypes and nicotine withdrawal scores. 1esults: An increased risk for relapse was associated with nicotine withdrawal sensitivity score (odds ratio, 1.25; 95% confidence interval, 1.10-1.42). A maximal NPL LOD score of 3.15, suggestive of significant linkage, was identified at chr6q26 for nicotine withdrawal sensitivity. Evaluation of 18 OPRM1 SNPs via the family-based association test with the nicotine withdrawal sensitivity score identified eight tagging SNPs with global P values

Original languageEnglish (US)
Pages (from-to)3399-3406
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number12
DOIs
StatePublished - Dec 2009
Externally publishedYes

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Nicotine
Single Nucleotide Polymorphism
Smoking
Substance Withdrawal Syndrome
Pedigree
Genotype
Recurrence
mu Opioid Receptor
Smoking Cessation
Microsatellite Repeats
Chromosomes
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. / Hardin, Jill; He, Yungang; Javitz, Harold S.; Wessel, Jennifer; Krasnow, Ruth E.; Tildesley, Elizabeth; Hops, Hyman; Swan, Gary E.; Bergen, Andrew W.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 18, No. 12, 12.2009, p. 3399-3406.

Research output: Contribution to journalArticle

Hardin, Jill ; He, Yungang ; Javitz, Harold S. ; Wessel, Jennifer ; Krasnow, Ruth E. ; Tildesley, Elizabeth ; Hops, Hyman ; Swan, Gary E. ; Bergen, Andrew W. / Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. In: Cancer Epidemiology Biomarkers and Prevention. 2009 ; Vol. 18, No. 12. pp. 3399-3406.
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