Nighttime insulin kinetics and glycemic control in type 1 diabetes patients following administration of an intermediate-acting lispro preparation

Maureen M J Janssen, Sandrina Casteleijn, Walter Devillé, Corrie Popp-Snijders, Paris Roach, Robert J. Heine

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

OBJECTIVE - To determine insulin kinetics and overnight glycemic control after bedtime administration of a new intermediate-acting insulin preparation called neutral protamine lispro (NPL). RESEARCH DESIGN AND METHODS - We studied 12 patients with well-controlled type 1 diabetes. The study had a double-blind, randomized, crossover design. After a lead-in period of 10-14 days two experiments were carried out with an interval of 2-7 days. During these experiments overnight insulin kinetics and fasting blood glucose levels were studied after evening administration of NPH insulin and NPL. Blood glucose levels

Original languageEnglish (US)
Pages (from-to)1870-1873
Number of pages4
JournalDiabetes Care
Volume20
Issue number12
StatePublished - Dec 1997
Externally publishedYes

Fingerprint

Insulin Lispro
Type 1 Diabetes Mellitus
Insulin
Blood Glucose
Isophane Insulin
Cross-Over Studies
Fasting
Research Design
neutral protamine lispro

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Janssen, M. M. J., Casteleijn, S., Devillé, W., Popp-Snijders, C., Roach, P., & Heine, R. J. (1997). Nighttime insulin kinetics and glycemic control in type 1 diabetes patients following administration of an intermediate-acting lispro preparation. Diabetes Care, 20(12), 1870-1873.

Nighttime insulin kinetics and glycemic control in type 1 diabetes patients following administration of an intermediate-acting lispro preparation. / Janssen, Maureen M J; Casteleijn, Sandrina; Devillé, Walter; Popp-Snijders, Corrie; Roach, Paris; Heine, Robert J.

In: Diabetes Care, Vol. 20, No. 12, 12.1997, p. 1870-1873.

Research output: Contribution to journalArticle

Janssen, MMJ, Casteleijn, S, Devillé, W, Popp-Snijders, C, Roach, P & Heine, RJ 1997, 'Nighttime insulin kinetics and glycemic control in type 1 diabetes patients following administration of an intermediate-acting lispro preparation', Diabetes Care, vol. 20, no. 12, pp. 1870-1873.
Janssen, Maureen M J ; Casteleijn, Sandrina ; Devillé, Walter ; Popp-Snijders, Corrie ; Roach, Paris ; Heine, Robert J. / Nighttime insulin kinetics and glycemic control in type 1 diabetes patients following administration of an intermediate-acting lispro preparation. In: Diabetes Care. 1997 ; Vol. 20, No. 12. pp. 1870-1873.
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