Nimodipine-enhanced survival of suboptimal neural grafts

Feng Zhou, C. F. Pu, S. Finger

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The present experiment was conducted to see whether nimodipine, a calcium channel blocker with the potential to protect vulnerable neurons, could improve the survival rate of striatal grafts under suboptimal conditions. The drug markedly improved graft viability of rats with near-term (E21) striatal implants. Untreated rats showed no surviving neurons while all treated rats showed surviving grafts rich in neuron. It did not affect the survival of striatal grafts from E14/15 donors into the striatum, in which the high rates of survival are normally obtained.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalRestorative Neurology and Neuroscience
Volume3
Issue number4
StatePublished - 1991

Fingerprint

Corpus Striatum
Nimodipine
Transplants
Neurons
Calcium Channel Blockers
Graft Survival
Pharmaceutical Preparations

Keywords

  • brain transplant
  • calcium channel blocker
  • graft
  • neurotoxicity
  • nimodipine
  • striatum
  • trauma

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Nimodipine-enhanced survival of suboptimal neural grafts. / Zhou, Feng; Pu, C. F.; Finger, S.

In: Restorative Neurology and Neuroscience, Vol. 3, No. 4, 1991, p. 211-215.

Research output: Contribution to journalArticle

Zhou, Feng ; Pu, C. F. ; Finger, S. / Nimodipine-enhanced survival of suboptimal neural grafts. In: Restorative Neurology and Neuroscience. 1991 ; Vol. 3, No. 4. pp. 211-215.
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