Nitric oxide modulates right ventricular flow and oxygen consumption during norepinephrine infusion

Srinath Setty, Johnathan D. Tune, H. Fred Downey

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

This study was designed to test if nitric oxide (NO) contributes to norepinephrine-induced right coronary vasodilation and if NO blunts the norepinephrine-induced increase in myocardial oxygen consumption (MVO2) in the right ventricle. In five anesthetized, open-chest dogs, mean aortic pressure, heart rate, right ventricular rate of pressure development over time (dP/dt), right coronary blood flow, and right ventricular MVO2 were measured before and during graded intracoronary infusions of norepinephrine in the absence and presence of a NO synthase blocker, Nω-nitro-L-arginine methyl ester (L-NAME; 150 μg/min ic). During both conditions, right coronary blood flow and right ventricular MVO2 significantly increased with graded infusions of norepinephrine. L-NAME significantly blunted the coronary hyperemic response to norepinephrine, although L-NAME did not alter the relationship between right ventricular MVO2 and norepinephrine dose. However, when right ventricular function was indexed by heart rate × right ventricular maximum dP/dt × peak right ventricular systolic pressure, L-NAME significantly increased the oxygen cost of right ventricular function. These results indicate that NO contributes to norepinephrine-induced right coronary vasodilation and improves right ventricular oxygen utilization efficiency.

Original languageEnglish (US)
Pages (from-to)H696-H703
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume282
Issue number2 51-2
DOIs
StatePublished - Jan 1 2002

Keywords

  • N-nitro-L-arginine methyl ester
  • Open-chest dogs
  • Right coronary circulation
  • Right ventricular oxygen utilization efficiency

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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