Nitrous oxide acutely suppresses ethanol consumption in HAD and P rats

Ann Kosobud, Clara Kebabian, George Rebec

Research output: Contribution to journalArticle

5 Scopus citations


Nitrous oxide (N 2 O) has been reported to reduce post-withdrawal craving in alcoholic humans, aiding in their continued abstinence. This article assessed the ability of N 2 O to suppress alcohol drinking in genetically selected high alcohol-drinking (HAD) and alcohol-preferring (P) rats. Although water was available ad libitum , they were accustomed to a limited access (1 h/day) choice between 10% ethanol (EtOH) and water. When drinking stabilized, the rats were exposed for 30, 60, or 120 min to a mixture of N 2 O and pure oxygen, timed to end 1 h before the limited access. N 2 O suppressed EtOH consumption at 1, but not 25 h after exposure in both HAD and P rats. This result is consistent with the efficacy of N 2 O for acute reduction of EtOH drinking, and supports further research into the use of N 2 O as an adjunct to treatment.

Original languageEnglish (US)
Pages (from-to)835-845
Number of pages11
JournalInternational Journal of Neuroscience
Issue number7
StatePublished - Jun 1 2006


  • Alcoholism
  • Drinking
  • Genetic models
  • Nitrous oxide
  • Pharmacotherapy
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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