Nitrous oxide acutely suppresses ethanol consumption in HAD and P rats

Ann Kosobud, Clara Kebabian, George Rebec

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Nitrous oxide (N 2 O) has been reported to reduce post-withdrawal craving in alcoholic humans, aiding in their continued abstinence. This article assessed the ability of N 2 O to suppress alcohol drinking in genetically selected high alcohol-drinking (HAD) and alcohol-preferring (P) rats. Although water was available ad libitum , they were accustomed to a limited access (1 h/day) choice between 10% ethanol (EtOH) and water. When drinking stabilized, the rats were exposed for 30, 60, or 120 min to a mixture of N 2 O and pure oxygen, timed to end 1 h before the limited access. N 2 O suppressed EtOH consumption at 1, but not 25 h after exposure in both HAD and P rats. This result is consistent with the efficacy of N 2 O for acute reduction of EtOH drinking, and supports further research into the use of N 2 O as an adjunct to treatment.

Original languageEnglish
Pages (from-to)835-845
Number of pages11
JournalInternational Journal of Neuroscience
Volume116
Issue number7
DOIs
StatePublished - Jun 1 2006

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Nitrous Oxide
Alcohol Drinking
Ethanol
Drinking
Aptitude
Water
Alcoholics
Alcohols
Oxygen
Research
Therapeutics

Keywords

  • Alcoholism
  • Drinking
  • Genetic models
  • Nitrous oxide
  • Pharmacotherapy
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nitrous oxide acutely suppresses ethanol consumption in HAD and P rats. / Kosobud, Ann; Kebabian, Clara; Rebec, George.

In: International Journal of Neuroscience, Vol. 116, No. 7, 01.06.2006, p. 835-845.

Research output: Contribution to journalArticle

Kosobud, Ann ; Kebabian, Clara ; Rebec, George. / Nitrous oxide acutely suppresses ethanol consumption in HAD and P rats. In: International Journal of Neuroscience. 2006 ; Vol. 116, No. 7. pp. 835-845.
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