Nizatidine, and H2-receptor antagonist

Disposition and safety in the elderly

John Callaghan, A. Rubin, M. P. Knadler, R. F. Bergstrom

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Nizatidine is an orally active H2-receptor blocker. Its disposition and safety in eight young and 12 elderly volunteers were investigated. Single oral doses of nizatidine were administered: from 100 mg to 300 mg in the elderly, and from 100 mg to 350 mg in the young. The nizatidine AUC was directly proportional to dose for both groups. Calculated pharmacokinetic variables in the elderly vs. the young were t( 1/2 ) = 1.9 vs. 1.6 hr; CL(p)/f = 32 vs. 40 L/hr, and Vd(β)/f = 1.2 vs 1.3 L/kg. The impaired renal function of some elderly volunteers prolonged nizatidine elimination and lowered its clearance. Renal impairment rather than advanced age per se was the predominant factor in decreasing the nizatidine elimination rate. Because Cl(cr) correlated directly with nizatidine renal clearance, Cl(cr) values may be used to estimate nizatidine dosage reductions in renal insufficiency. During the trial, no serious adverse effects occurred.

Original languageEnglish (US)
Pages (from-to)618-624
Number of pages7
JournalJournal of Clinical Pharmacology
Volume27
Issue number8
StatePublished - 1987

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Nizatidine
Histamine H2 Receptors
Safety
Kidney
Volunteers
Area Under Curve
Renal Insufficiency
Pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Nizatidine, and H2-receptor antagonist : Disposition and safety in the elderly. / Callaghan, John; Rubin, A.; Knadler, M. P.; Bergstrom, R. F.

In: Journal of Clinical Pharmacology, Vol. 27, No. 8, 1987, p. 618-624.

Research output: Contribution to journalArticle

Callaghan, John ; Rubin, A. ; Knadler, M. P. ; Bergstrom, R. F. / Nizatidine, and H2-receptor antagonist : Disposition and safety in the elderly. In: Journal of Clinical Pharmacology. 1987 ; Vol. 27, No. 8. pp. 618-624.
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