NMDA R1 mRNA distribution in motor and thalamic-projecting sensory neurons in the rat spinal cord and brain stem

Laura Kus, Dale Saxon, Alvin J. Beitz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The N-methyl-D-aspartate (NMDA) receptor is important in both sensory and motor neurotransmission. In this study we examine NMDA R1 mRNA hybridization signal over individual sensory and motor neurons in the spinal cord and brain stem. A significantly greater quantity of NMDA RI mRNA was present in motor neurons of the lumbar spinal cord and hypoglossal nucleus compared to thalamic projecting sensory neurons in the spinal cord dorsal horn, the spinal trigeminal nucleus pars caudalis and the cuneate and gracile nuclei. No significant difference in the quantity of NMDA R1 mRNA was observed between sensory neurons known to relay predominantly nociceptive information (trigeminothalamic and spinothalamic tract neurons) and those that relay predominantly touch and proprioceptive information (dorsal column neurons).

Original languageEnglish (US)
Pages (from-to)201-204
Number of pages4
JournalNeuroscience Letters
Volume196
Issue number2
DOIs
StatePublished - Aug 25 1995
Externally publishedYes

Fingerprint

Sensory Receptor Cells
N-Methylaspartate
Brain Stem
Spinal Cord
Motor Neurons
Messenger RNA
Spinothalamic Tracts
Spinal Trigeminal Nucleus
Neurons
Touch
N-Methyl-D-Aspartate Receptors
Synaptic Transmission

Keywords

  • Dorsal column nuclei
  • Hypoglossal
  • In situ hybridization
  • Motor neurons
  • NMDA
  • NMDA R1
  • Spinal cord
  • Spinothalamic

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

NMDA R1 mRNA distribution in motor and thalamic-projecting sensory neurons in the rat spinal cord and brain stem. / Kus, Laura; Saxon, Dale; Beitz, Alvin J.

In: Neuroscience Letters, Vol. 196, No. 2, 25.08.1995, p. 201-204.

Research output: Contribution to journalArticle

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