NMDA receptor function and human cognition

The effects of ketamine in healthy volunteers

Anil K. Malhotra, Debra A. Pinals, Herbert Weingartner, Karen Sirocco, C. David Missar, David Pickar, Alan Breier

Research output: Contribution to journalArticle

506 Citations (Scopus)

Abstract

A rapidly growing body of preclinical data has implicated the glutamatergic N-methyl-d-aspartate (NMDA) receptor in memory and other cognitive processes. There is comparatively less information about this receptor system in human cognition. We examined the effects of subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, on two forms of memory, free recall and recognition, as well as attention and behavior in a double-blind, placebo-controlled, 1-hour infusion in 15 healthy volunteers. Ketamine produced decrements in free recall, recognition memory, and attention. In addition, ketamine induced a brief psychosis in our healthy volunteers marked by thought disorder and withdrawal-retardation. Ketamine-induced memory impairments were not accounted for by changes in subject's attention and were not significantly related to psychosis ratings. These data suggest that the NMDA receptor plays a direct role in two types of explicit memory. The implications of these data for the pathophysiology of schizophrenia are discussed.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalNeuropsychopharmacology
Volume14
Issue number5
DOIs
StatePublished - May 1996
Externally publishedYes

Fingerprint

Ketamine
Cognition
Healthy Volunteers
Psychotic Disorders
Schizophrenia
Placebos
aspartic acid receptor
Recognition (Psychology)

Keywords

  • Cognition
  • Ketamine
  • Memory
  • Psychotic disorders
  • Receptors, glutamate
  • Receptors, N-methyl-d-aspartate

ASJC Scopus subject areas

  • Pharmacology

Cite this

Malhotra, A. K., Pinals, D. A., Weingartner, H., Sirocco, K., Missar, C. D., Pickar, D., & Breier, A. (1996). NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers. Neuropsychopharmacology, 14(5), 301-307. https://doi.org/10.1016/0893-133X(95)00137-3

NMDA receptor function and human cognition : The effects of ketamine in healthy volunteers. / Malhotra, Anil K.; Pinals, Debra A.; Weingartner, Herbert; Sirocco, Karen; Missar, C. David; Pickar, David; Breier, Alan.

In: Neuropsychopharmacology, Vol. 14, No. 5, 05.1996, p. 301-307.

Research output: Contribution to journalArticle

Malhotra, AK, Pinals, DA, Weingartner, H, Sirocco, K, Missar, CD, Pickar, D & Breier, A 1996, 'NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers', Neuropsychopharmacology, vol. 14, no. 5, pp. 301-307. https://doi.org/10.1016/0893-133X(95)00137-3
Malhotra AK, Pinals DA, Weingartner H, Sirocco K, Missar CD, Pickar D et al. NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers. Neuropsychopharmacology. 1996 May;14(5):301-307. https://doi.org/10.1016/0893-133X(95)00137-3
Malhotra, Anil K. ; Pinals, Debra A. ; Weingartner, Herbert ; Sirocco, Karen ; Missar, C. David ; Pickar, David ; Breier, Alan. / NMDA receptor function and human cognition : The effects of ketamine in healthy volunteers. In: Neuropsychopharmacology. 1996 ; Vol. 14, No. 5. pp. 301-307.
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