NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers

Anil K. Malhotra, Debra A. Pinals, Herbert Weingartner, Karen Sirocco, C. David Missar, David Pickar, Alan Breier

Research output: Contribution to journalArticle

509 Citations (Scopus)

Abstract

A rapidly growing body of preclinical data has implicated the glutamatergic N-methyl-d-aspartate (NMDA) receptor in memory and other cognitive processes. There is comparatively less information about this receptor system in human cognition. We examined the effects of subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, on two forms of memory, free recall and recognition, as well as attention and behavior in a double-blind, placebo-controlled, 1-hour infusion in 15 healthy volunteers. Ketamine produced decrements in free recall, recognition memory, and attention. In addition, ketamine induced a brief psychosis in our healthy volunteers marked by thought disorder and withdrawal-retardation. Ketamine-induced memory impairments were not accounted for by changes in subject's attention and were not significantly related to psychosis ratings. These data suggest that the NMDA receptor plays a direct role in two types of explicit memory. The implications of these data for the pathophysiology of schizophrenia are discussed.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalNeuropsychopharmacology
Volume14
Issue number5
DOIs
StatePublished - May 1996
Externally publishedYes

Fingerprint

Ketamine
Cognition
Healthy Volunteers
Psychotic Disorders
Schizophrenia
Placebos
aspartic acid receptor
Recognition (Psychology)

Keywords

  • Cognition
  • Ketamine
  • Memory
  • Psychotic disorders
  • Receptors, glutamate
  • Receptors, N-methyl-d-aspartate

ASJC Scopus subject areas

  • Pharmacology

Cite this

Malhotra, A. K., Pinals, D. A., Weingartner, H., Sirocco, K., Missar, C. D., Pickar, D., & Breier, A. (1996). NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers. Neuropsychopharmacology, 14(5), 301-307. https://doi.org/10.1016/0893-133X(95)00137-3

NMDA receptor function and human cognition : The effects of ketamine in healthy volunteers. / Malhotra, Anil K.; Pinals, Debra A.; Weingartner, Herbert; Sirocco, Karen; Missar, C. David; Pickar, David; Breier, Alan.

In: Neuropsychopharmacology, Vol. 14, No. 5, 05.1996, p. 301-307.

Research output: Contribution to journalArticle

Malhotra, AK, Pinals, DA, Weingartner, H, Sirocco, K, Missar, CD, Pickar, D & Breier, A 1996, 'NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers', Neuropsychopharmacology, vol. 14, no. 5, pp. 301-307. https://doi.org/10.1016/0893-133X(95)00137-3
Malhotra AK, Pinals DA, Weingartner H, Sirocco K, Missar CD, Pickar D et al. NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers. Neuropsychopharmacology. 1996 May;14(5):301-307. https://doi.org/10.1016/0893-133X(95)00137-3
Malhotra, Anil K. ; Pinals, Debra A. ; Weingartner, Herbert ; Sirocco, Karen ; Missar, C. David ; Pickar, David ; Breier, Alan. / NMDA receptor function and human cognition : The effects of ketamine in healthy volunteers. In: Neuropsychopharmacology. 1996 ; Vol. 14, No. 5. pp. 301-307.
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