N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents

Tien L. Huang, Bin Tao, Yvonne Quarshie, Sherry Queener, Isaac O. Donkor

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The synthesis, anti-Pneumocystis carinii activity and DNA binding properties of eight new N,N′-bis[4-(N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 μM concentrations.

Original languageEnglish
Pages (from-to)2679-2681
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number20
DOIs
StatePublished - Oct 22 2001

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Pneumocystis carinii
Cell culture
DNA
Cell Culture Techniques
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents. / Huang, Tien L.; Tao, Bin; Quarshie, Yvonne; Queener, Sherry; Donkor, Isaac O.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 20, 22.10.2001, p. 2679-2681.

Research output: Contribution to journalArticle

Huang, Tien L. ; Tao, Bin ; Quarshie, Yvonne ; Queener, Sherry ; Donkor, Isaac O. / N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 20. pp. 2679-2681.
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