N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents

Tien L. Huang, Bin Tao, Yvonne Quarshie, Sherry F. Queener, Isaac O. Donkor

Research output: Contribution to journalArticle

17 Scopus citations


The synthesis, anti-Pneumocystis carinii activity and DNA binding properties of eight new N,N′-bis[4-(N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 μM concentrations.

Original languageEnglish (US)
Pages (from-to)2679-2681
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number20
StatePublished - Oct 22 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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