No association between telomere length-related loci and number of cutaneous nevi

Xin Li, Geyu Liang, Mengmeng Du, Immaculata De Vivo, Hongmei Nan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Longer telomeres have been associated both with increased melanoma risk and increased nevus counts. Nevus count is one of the strongest risk factors for melanoma. Recent data showed that a genetic score derived by telomere length-related single nucleotide polymorphisms (SNPs) was strongly associated with melanoma risk; however, the relationships between these SNPs and number of cutaneous nevi have not been investigated. Methods: We evaluated the associations between telomere length-related SNPs reported by previous genome-wide association study (GWAS) and nevus counts among 15,955 participants of European Ancestry in the Nurses' Health Study and Health Professionals Follow-up Study. Results: None of the SNPs was associated with nevus counts, nor was the genetic score combining the dosage of alleles related to increased telomere length. Conclusions: The telomere length-related SNPs identified by published GWAS do not appear to play an important role in nevus formation. Genetic determinants of telomere length reported by GWAS do not explain the observed epidemiologic association between telomere length and nevus counts.

Original languageEnglish (US)
Pages (from-to)82396-82399
Number of pages4
JournalOncotarget
Volume7
Issue number50
DOIs
StatePublished - Jan 1 2016

Fingerprint

Nevus
Telomere
Single Nucleotide Polymorphism
Skin
Genome-Wide Association Study
Melanoma
Health
Alleles
Nurses

Keywords

  • Genetic score
  • Genome-wide association study
  • Melanoma
  • Nevus count
  • Telomere length-related loci

ASJC Scopus subject areas

  • Oncology

Cite this

No association between telomere length-related loci and number of cutaneous nevi. / Li, Xin; Liang, Geyu; Du, Mengmeng; De Vivo, Immaculata; Nan, Hongmei.

In: Oncotarget, Vol. 7, No. 50, 01.01.2016, p. 82396-82399.

Research output: Contribution to journalArticle

Li, Xin ; Liang, Geyu ; Du, Mengmeng ; De Vivo, Immaculata ; Nan, Hongmei. / No association between telomere length-related loci and number of cutaneous nevi. In: Oncotarget. 2016 ; Vol. 7, No. 50. pp. 82396-82399.
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