No difference in transplant outcomes for local and import pancreas allografts

Jonathan A. Fridell, Richard S. Mangus, Edward F. Hollinger, Martin L. Milgrom, Tim E. Taber, Elaine Mohler, Jason Good, Michelle L. Goble, John A. Powelson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background. In the United States, pancreas allograft allocation is strictly regulated. Local centers have the first option to accept an organ, followed by regional and national allocation for those not accepted locally. For a pancreas to be imported, many centers must have previously rejected the organ for transplantation. This study reviews the outcomes of all pancreas allografts transplanted at a single center between January 2003 and November 2007. Early graft function and graft survival were stratified by geographic source of the donor pancreas. Methods. The records of 247 pancreas recipients and the donors of 11 imported and discarded pancreas allografts were reviewed. Pancreas allograft survival is represented using a Kaplan-Meier survival curve comparing (1) locally procured and imported pancreas grafts and (2) grafts procured by a team from our own center with the grafts procured by another team. Results. Of the 247 grafts, 184 (74%) were local and 63 (26%) were imported. There were no differences between the two geographic groups in 1-year graft survival (local 91%, import 90%, P= 0.76). Similarly, graft survival was similar regardless of whether the organ was procured by our own team or by another center (local team 91%, another team 90%, P= 0.96). Conclusions. Pancreas allografts refused by a large number of centers may still be imported and successfully transplanted without affecting survival results.

Original languageEnglish (US)
Pages (from-to)723-728
Number of pages6
JournalTransplantation
Volume88
Issue number5
DOIs
StatePublished - Sep 15 2009

Keywords

  • Extended criteria donor
  • Pancreas allocation
  • Pancreas transplantation
  • Survival
  • Transplant outcomes

ASJC Scopus subject areas

  • Transplantation

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