No evidence of Epstein-Barr virus association with Merkel cell carcinoma

Maren Shaw, Simon Warren, Pamela Groben, Margaret L. Gulley

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Merkel cell carcinoma (MCC) is an aggressive tumor of cutaneous neuroendocrine cells with a reported 13-fold increased incidence in immunocompromised patients, raising the possibility that it is driven by an oncogenic virus. Additionally, Merkel cell hyperplasia is seen in the Epstein-Barr virus (EBV)-driven process oral hairy leukoplakia, and EBV is known to be involved in the pathogenesis of several other malignancies. Objective: We tested the hypothesis that EBV is involved in MCC. Methods: We employed EBV-encoded RNA in situ hybridization (ISH), lytic EBV ISH, latent membrane protein 1 immunohistochemistry, and BamH1Z leftward reading frame 1 immunohistochemistry to detect and localize EBV in paraffin sections of MCC from five patients as well as seven other cutaneous tumors and positive controls for EBV infection. Results: Positive controls reacted appropriately. However, there was no evidence of latent or lytic EBV in any of the MCC biopsies or other cutaneous tumors. Conclusion: Our findings suggest that EBV is not associated with MCC.

Original languageEnglish (US)
Pages (from-to)624-628
Number of pages5
JournalJournal of Cutaneous Pathology
Volume33
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

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Merkel Cell Carcinoma
Human Herpesvirus 4
Skin
In Situ Hybridization
Neoplasms
Hairy Leukoplakia
Merkel Cells
Immunohistochemistry
Reading Frames
Neuroendocrine Cells
Oncogenic Viruses
Epstein-Barr Virus Infections
Immunocompromised Host
Paraffin
Hyperplasia
Membrane Proteins
RNA
Biopsy
Incidence

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

No evidence of Epstein-Barr virus association with Merkel cell carcinoma. / Shaw, Maren; Warren, Simon; Groben, Pamela; Gulley, Margaret L.

In: Journal of Cutaneous Pathology, Vol. 33, No. 9, 09.2006, p. 624-628.

Research output: Contribution to journalArticle

Shaw, Maren ; Warren, Simon ; Groben, Pamela ; Gulley, Margaret L. / No evidence of Epstein-Barr virus association with Merkel cell carcinoma. In: Journal of Cutaneous Pathology. 2006 ; Vol. 33, No. 9. pp. 624-628.
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