Nobori stent shows less vascular inflammation and early recovery of endothelial function compared with cypher stent

Lakshmana K. Pendyala, Daisuke Matsumoto, Toshiro Shinke, Taizo Iwasaki, Ryota Sugimoto, Dongming Hou, Jack P. Chen, Jaipal Singh, Spencer B. King, Nicolas Chronos, Jinsheng Li

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Objectives: The current study sought to examine inflammation at the stented segments of Nobori (Terumo Corporation, Tokyo, Japan) and Cypher (Cordis, Miami, Florida) drug-eluting stents (DES), as well as free radical production and endothelial function of the adjacent nonstented segments in a pig coronary model. Background: Nobori is a novel DES, incorporating a biolimus A9-eluting biodegradable polymer coated only on the abluminal surface of the stent. These unique features may favorably affect inflammation and endothelial function, as compared to the currently marketed DES. Presently, pre-clinical data on direct comparison of the various generations of DES are not available. Methods: A total of 18 DES were implanted in pig coronary arteries and subsequently explanted at 1 month. Stented segments were assessed by angiography and histology. Ex vivo vasomotor function and superoxide production in segments proximal and distal to the stent were determined. The vasoconstriction, endothelial-dependent relaxation, and endothelial-independent relaxation of proximal and distal nonstented segments were measured. Results: Histological evaluation revealed lower inflammatory response with Nobori than with Cypher DES. There is trend for lower angiographic percentage diameter stenosis in Nobori versus Cypher groups (p = 0.054). There was increased endothelium-dependent relaxation, decreased endothelin-1-mediated contraction, and less superoxide production in the vessel segments proximal and distal to Nobori versus Cypher stents. Conclusions: Our data show significantly lower inflammatory response in the stented segments, and rapid recovery of endothelial function of peristent segments in the Nobori group compared with Cypher DES group at 1 month in porcine coronary artery model.

Original languageEnglish (US)
Pages (from-to)436-444
Number of pages9
JournalJACC: Cardiovascular Interventions
Volume5
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

Fingerprint

Drug-Eluting Stents
Recovery of Function
Stents
Blood Vessels
Inflammation
Swine
Superoxides
Coronary Vessels
Tokyo
Endothelin-1
Vasoconstriction
Free Radicals
Endothelium
Histology
Angiography
Japan
Polymers
Pathologic Constriction

Keywords

  • biolimus A9-eluting stent(s)
  • coronary arteries
  • endothelial function
  • inflammation
  • oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nobori stent shows less vascular inflammation and early recovery of endothelial function compared with cypher stent. / Pendyala, Lakshmana K.; Matsumoto, Daisuke; Shinke, Toshiro; Iwasaki, Taizo; Sugimoto, Ryota; Hou, Dongming; Chen, Jack P.; Singh, Jaipal; King, Spencer B.; Chronos, Nicolas; Li, Jinsheng.

In: JACC: Cardiovascular Interventions, Vol. 5, No. 4, 04.2012, p. 436-444.

Research output: Contribution to journalReview article

Pendyala, LK, Matsumoto, D, Shinke, T, Iwasaki, T, Sugimoto, R, Hou, D, Chen, JP, Singh, J, King, SB, Chronos, N & Li, J 2012, 'Nobori stent shows less vascular inflammation and early recovery of endothelial function compared with cypher stent', JACC: Cardiovascular Interventions, vol. 5, no. 4, pp. 436-444. https://doi.org/10.1016/j.jcin.2011.11.013
Pendyala, Lakshmana K. ; Matsumoto, Daisuke ; Shinke, Toshiro ; Iwasaki, Taizo ; Sugimoto, Ryota ; Hou, Dongming ; Chen, Jack P. ; Singh, Jaipal ; King, Spencer B. ; Chronos, Nicolas ; Li, Jinsheng. / Nobori stent shows less vascular inflammation and early recovery of endothelial function compared with cypher stent. In: JACC: Cardiovascular Interventions. 2012 ; Vol. 5, No. 4. pp. 436-444.
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abstract = "Objectives: The current study sought to examine inflammation at the stented segments of Nobori (Terumo Corporation, Tokyo, Japan) and Cypher (Cordis, Miami, Florida) drug-eluting stents (DES), as well as free radical production and endothelial function of the adjacent nonstented segments in a pig coronary model. Background: Nobori is a novel DES, incorporating a biolimus A9-eluting biodegradable polymer coated only on the abluminal surface of the stent. These unique features may favorably affect inflammation and endothelial function, as compared to the currently marketed DES. Presently, pre-clinical data on direct comparison of the various generations of DES are not available. Methods: A total of 18 DES were implanted in pig coronary arteries and subsequently explanted at 1 month. Stented segments were assessed by angiography and histology. Ex vivo vasomotor function and superoxide production in segments proximal and distal to the stent were determined. The vasoconstriction, endothelial-dependent relaxation, and endothelial-independent relaxation of proximal and distal nonstented segments were measured. Results: Histological evaluation revealed lower inflammatory response with Nobori than with Cypher DES. There is trend for lower angiographic percentage diameter stenosis in Nobori versus Cypher groups (p = 0.054). There was increased endothelium-dependent relaxation, decreased endothelin-1-mediated contraction, and less superoxide production in the vessel segments proximal and distal to Nobori versus Cypher stents. Conclusions: Our data show significantly lower inflammatory response in the stented segments, and rapid recovery of endothelial function of peristent segments in the Nobori group compared with Cypher DES group at 1 month in porcine coronary artery model.",
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T1 - Nobori stent shows less vascular inflammation and early recovery of endothelial function compared with cypher stent

AU - Pendyala, Lakshmana K.

AU - Matsumoto, Daisuke

AU - Shinke, Toshiro

AU - Iwasaki, Taizo

AU - Sugimoto, Ryota

AU - Hou, Dongming

AU - Chen, Jack P.

AU - Singh, Jaipal

AU - King, Spencer B.

AU - Chronos, Nicolas

AU - Li, Jinsheng

PY - 2012/4

Y1 - 2012/4

N2 - Objectives: The current study sought to examine inflammation at the stented segments of Nobori (Terumo Corporation, Tokyo, Japan) and Cypher (Cordis, Miami, Florida) drug-eluting stents (DES), as well as free radical production and endothelial function of the adjacent nonstented segments in a pig coronary model. Background: Nobori is a novel DES, incorporating a biolimus A9-eluting biodegradable polymer coated only on the abluminal surface of the stent. These unique features may favorably affect inflammation and endothelial function, as compared to the currently marketed DES. Presently, pre-clinical data on direct comparison of the various generations of DES are not available. Methods: A total of 18 DES were implanted in pig coronary arteries and subsequently explanted at 1 month. Stented segments were assessed by angiography and histology. Ex vivo vasomotor function and superoxide production in segments proximal and distal to the stent were determined. The vasoconstriction, endothelial-dependent relaxation, and endothelial-independent relaxation of proximal and distal nonstented segments were measured. Results: Histological evaluation revealed lower inflammatory response with Nobori than with Cypher DES. There is trend for lower angiographic percentage diameter stenosis in Nobori versus Cypher groups (p = 0.054). There was increased endothelium-dependent relaxation, decreased endothelin-1-mediated contraction, and less superoxide production in the vessel segments proximal and distal to Nobori versus Cypher stents. Conclusions: Our data show significantly lower inflammatory response in the stented segments, and rapid recovery of endothelial function of peristent segments in the Nobori group compared with Cypher DES group at 1 month in porcine coronary artery model.

AB - Objectives: The current study sought to examine inflammation at the stented segments of Nobori (Terumo Corporation, Tokyo, Japan) and Cypher (Cordis, Miami, Florida) drug-eluting stents (DES), as well as free radical production and endothelial function of the adjacent nonstented segments in a pig coronary model. Background: Nobori is a novel DES, incorporating a biolimus A9-eluting biodegradable polymer coated only on the abluminal surface of the stent. These unique features may favorably affect inflammation and endothelial function, as compared to the currently marketed DES. Presently, pre-clinical data on direct comparison of the various generations of DES are not available. Methods: A total of 18 DES were implanted in pig coronary arteries and subsequently explanted at 1 month. Stented segments were assessed by angiography and histology. Ex vivo vasomotor function and superoxide production in segments proximal and distal to the stent were determined. The vasoconstriction, endothelial-dependent relaxation, and endothelial-independent relaxation of proximal and distal nonstented segments were measured. Results: Histological evaluation revealed lower inflammatory response with Nobori than with Cypher DES. There is trend for lower angiographic percentage diameter stenosis in Nobori versus Cypher groups (p = 0.054). There was increased endothelium-dependent relaxation, decreased endothelin-1-mediated contraction, and less superoxide production in the vessel segments proximal and distal to Nobori versus Cypher stents. Conclusions: Our data show significantly lower inflammatory response in the stented segments, and rapid recovery of endothelial function of peristent segments in the Nobori group compared with Cypher DES group at 1 month in porcine coronary artery model.

KW - biolimus A9-eluting stent(s)

KW - coronary arteries

KW - endothelial function

KW - inflammation

KW - oxidative stress

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