Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome

M. Pombo, E. Herrera-Justiniano, Robert Considine, R. C. Hermida, M. J. Galvez, T. Martin, J. Barreiro, F. F. Casanueva, C. Dieguez

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We studied 24-h profiles of circulating leptin levels using a sensitive and specific radioimmunoassay in healthy pre- (Tanner 1) and pubertal boys and girls (Tanner 3-4) as well as in a group of patients with perinatal stalk-transection syndrome. Similar nyctohemeral rhythm in serum leptin levels were found in prepubertal (MESOR: 2.34±0.2 ng/ml; amplitude 0.32±0.1 ng/ml) and pubertal boys (MESOR 2.2±0.2 ng/ml; amplitude 0.38±0.07 ng/ml). Likewise, no differences were found between prepubertal (MESOR 6.6 ± 1.07 ng/ml; amplitude 1.67±0.4 ng/ml) and pubertal girls (MESOR 4.05±0.5 ng/ml; amplitude 0.95±0.2 ng/ml). In contrast, higher MESOR (p<0.002) and amplitude values (p<0.005) were found in prepubertal and pubertal girls than in prepubertal and pubertal boys. Finally a significant nyctohemeral rhythm in serum leptin levels was found in patients with perinatal stalk-transection syndrome (MESOR: 9.3±2.3 ng/ml; amplitude 1.46±0.4 ng/ml). This data shows the existence of sexual dimorphism in the nyctohemeral rhythm in serum leptin levels that are not influenced by the pubertal stage or by pulsatile anterior pituitary hormone secretion.

Original languageEnglish
Pages (from-to)2751-2754
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume82
Issue number8
DOIs
StatePublished - 1997

Fingerprint

Leptin
Circadian Rhythm
Serum
Anterior Pituitary Hormones
Sex Characteristics
Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome. / Pombo, M.; Herrera-Justiniano, E.; Considine, Robert; Hermida, R. C.; Galvez, M. J.; Martin, T.; Barreiro, J.; Casanueva, F. F.; Dieguez, C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 82, No. 8, 1997, p. 2751-2754.

Research output: Contribution to journalArticle

Pombo, M, Herrera-Justiniano, E, Considine, R, Hermida, RC, Galvez, MJ, Martin, T, Barreiro, J, Casanueva, FF & Dieguez, C 1997, 'Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 8, pp. 2751-2754. https://doi.org/10.1210/jc.82.8.2751
Pombo, M. ; Herrera-Justiniano, E. ; Considine, Robert ; Hermida, R. C. ; Galvez, M. J. ; Martin, T. ; Barreiro, J. ; Casanueva, F. F. ; Dieguez, C. / Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome. In: Journal of Clinical Endocrinology and Metabolism. 1997 ; Vol. 82, No. 8. pp. 2751-2754.
@article{031cb14f086345bba46ae421be3a140e,
title = "Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome",
abstract = "We studied 24-h profiles of circulating leptin levels using a sensitive and specific radioimmunoassay in healthy pre- (Tanner 1) and pubertal boys and girls (Tanner 3-4) as well as in a group of patients with perinatal stalk-transection syndrome. Similar nyctohemeral rhythm in serum leptin levels were found in prepubertal (MESOR: 2.34±0.2 ng/ml; amplitude 0.32±0.1 ng/ml) and pubertal boys (MESOR 2.2±0.2 ng/ml; amplitude 0.38±0.07 ng/ml). Likewise, no differences were found between prepubertal (MESOR 6.6 ± 1.07 ng/ml; amplitude 1.67±0.4 ng/ml) and pubertal girls (MESOR 4.05±0.5 ng/ml; amplitude 0.95±0.2 ng/ml). In contrast, higher MESOR (p<0.002) and amplitude values (p<0.005) were found in prepubertal and pubertal girls than in prepubertal and pubertal boys. Finally a significant nyctohemeral rhythm in serum leptin levels was found in patients with perinatal stalk-transection syndrome (MESOR: 9.3±2.3 ng/ml; amplitude 1.46±0.4 ng/ml). This data shows the existence of sexual dimorphism in the nyctohemeral rhythm in serum leptin levels that are not influenced by the pubertal stage or by pulsatile anterior pituitary hormone secretion.",
author = "M. Pombo and E. Herrera-Justiniano and Robert Considine and Hermida, {R. C.} and Galvez, {M. J.} and T. Martin and J. Barreiro and Casanueva, {F. F.} and C. Dieguez",
year = "1997",
doi = "10.1210/jc.82.8.2751",
language = "English",
volume = "82",
pages = "2751--2754",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "8",

}

TY - JOUR

T1 - Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome

AU - Pombo, M.

AU - Herrera-Justiniano, E.

AU - Considine, Robert

AU - Hermida, R. C.

AU - Galvez, M. J.

AU - Martin, T.

AU - Barreiro, J.

AU - Casanueva, F. F.

AU - Dieguez, C.

PY - 1997

Y1 - 1997

N2 - We studied 24-h profiles of circulating leptin levels using a sensitive and specific radioimmunoassay in healthy pre- (Tanner 1) and pubertal boys and girls (Tanner 3-4) as well as in a group of patients with perinatal stalk-transection syndrome. Similar nyctohemeral rhythm in serum leptin levels were found in prepubertal (MESOR: 2.34±0.2 ng/ml; amplitude 0.32±0.1 ng/ml) and pubertal boys (MESOR 2.2±0.2 ng/ml; amplitude 0.38±0.07 ng/ml). Likewise, no differences were found between prepubertal (MESOR 6.6 ± 1.07 ng/ml; amplitude 1.67±0.4 ng/ml) and pubertal girls (MESOR 4.05±0.5 ng/ml; amplitude 0.95±0.2 ng/ml). In contrast, higher MESOR (p<0.002) and amplitude values (p<0.005) were found in prepubertal and pubertal girls than in prepubertal and pubertal boys. Finally a significant nyctohemeral rhythm in serum leptin levels was found in patients with perinatal stalk-transection syndrome (MESOR: 9.3±2.3 ng/ml; amplitude 1.46±0.4 ng/ml). This data shows the existence of sexual dimorphism in the nyctohemeral rhythm in serum leptin levels that are not influenced by the pubertal stage or by pulsatile anterior pituitary hormone secretion.

AB - We studied 24-h profiles of circulating leptin levels using a sensitive and specific radioimmunoassay in healthy pre- (Tanner 1) and pubertal boys and girls (Tanner 3-4) as well as in a group of patients with perinatal stalk-transection syndrome. Similar nyctohemeral rhythm in serum leptin levels were found in prepubertal (MESOR: 2.34±0.2 ng/ml; amplitude 0.32±0.1 ng/ml) and pubertal boys (MESOR 2.2±0.2 ng/ml; amplitude 0.38±0.07 ng/ml). Likewise, no differences were found between prepubertal (MESOR 6.6 ± 1.07 ng/ml; amplitude 1.67±0.4 ng/ml) and pubertal girls (MESOR 4.05±0.5 ng/ml; amplitude 0.95±0.2 ng/ml). In contrast, higher MESOR (p<0.002) and amplitude values (p<0.005) were found in prepubertal and pubertal girls than in prepubertal and pubertal boys. Finally a significant nyctohemeral rhythm in serum leptin levels was found in patients with perinatal stalk-transection syndrome (MESOR: 9.3±2.3 ng/ml; amplitude 1.46±0.4 ng/ml). This data shows the existence of sexual dimorphism in the nyctohemeral rhythm in serum leptin levels that are not influenced by the pubertal stage or by pulsatile anterior pituitary hormone secretion.

UR - http://www.scopus.com/inward/record.url?scp=0030838451&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030838451&partnerID=8YFLogxK

U2 - 10.1210/jc.82.8.2751

DO - 10.1210/jc.82.8.2751

M3 - Article

C2 - 9253365

AN - SCOPUS:0030838451

VL - 82

SP - 2751

EP - 2754

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 8

ER -