Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome

M. Pombo, E. Herrera-Justiniano, R. V. Considine, R. C. Hermida, M. J. Galvez, T. Martin, J. Barreiro, F. F. Casanueva, C. Dieguez

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

We studied 24-h profiles of circulating leptin levels using a sensitive and specific radioimmunoassay in healthy pre- (Tanner 1) and pubertal boys and girls (Tanner 3-4) as well as in a group of patients with perinatal stalk-transection syndrome. Similar nyctohemeral rhythm in serum leptin levels were found in prepubertal (MESOR: 2.34±0.2 ng/ml; amplitude 0.32±0.1 ng/ml) and pubertal boys (MESOR 2.2±0.2 ng/ml; amplitude 0.38±0.07 ng/ml). Likewise, no differences were found between prepubertal (MESOR 6.6 ± 1.07 ng/ml; amplitude 1.67±0.4 ng/ml) and pubertal girls (MESOR 4.05±0.5 ng/ml; amplitude 0.95±0.2 ng/ml). In contrast, higher MESOR (p<0.002) and amplitude values (p<0.005) were found in prepubertal and pubertal girls than in prepubertal and pubertal boys. Finally a significant nyctohemeral rhythm in serum leptin levels was found in patients with perinatal stalk-transection syndrome (MESOR: 9.3±2.3 ng/ml; amplitude 1.46±0.4 ng/ml). This data shows the existence of sexual dimorphism in the nyctohemeral rhythm in serum leptin levels that are not influenced by the pubertal stage or by pulsatile anterior pituitary hormone secretion.

Original languageEnglish (US)
Pages (from-to)2751-2754
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume82
Issue number8
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Pombo, M., Herrera-Justiniano, E., Considine, R. V., Hermida, R. C., Galvez, M. J., Martin, T., Barreiro, J., Casanueva, F. F., & Dieguez, C. (1997). Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome. Journal of Clinical Endocrinology and Metabolism, 82(8), 2751-2754. https://doi.org/10.1210/jcem.82.8.4049