Non-ampullary duodenal adenocarcinoma: Factors important for relapse and survival

Aaron Struck, Thomas Howard, Elena G. Chiorean, Jeffrey M. Clarke, Robert Riffenburgh, Higinia R. Cardenes

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Background: Duodenal adenocarcinoma (DA) is rare, but potentially curable. Prospective data on treatment outcomes is scarce and large retrospective studies show conflicting results on the impact of radical resection, node-status, and adjuvant therapy. Methods: In the past 17 years, 30 patients presented with resectable DA. Data on the aforementioned variables were acquired then analyzed for impact on recurrence and survival. Results: Overall-survival rates at 1, 2, and 3 years were 70.0%, 53.3%, and 33.3% respectively. Recurrence-free survival rates at 1, 2, and 3 years were 53.3%, 30.0%, and 26.7%. Overall-survival rates for patients with node-positive disease at 1, 2, and 3 years were 68.8%, 43.8%, 12.5%, and for node-negative 70%, 60%, 60%. Recurrence-free survival in node-positive disease at 1, 2, 3 years was 50%, 12.5%, 12.5%, and for node negative 50%, 50%, and 40%. Median survival from diagnosis was 27.5 months (0.5-226.7 months). Significant predictors of recurrence and survival were nodal-status and AJCC stage (P < 0.001). Adjuvant therapy, surgical-type, pathological tumor-stage, and surgical margins were not significant. Conclusion: Nodal-status and overall pathological-stage significantly affect the prognosis for patients withDA, while resection-status and adjuvant therapy may not. The role of adjuvant therapy requires prospective trials for elucidation.

Original languageEnglish (US)
Pages (from-to)144-148
Number of pages5
JournalJournal of Surgical Oncology
Volume100
Issue number2
DOIs
StatePublished - Aug 1 2009

Keywords

  • Adjuvant therapy
  • Nodal status
  • Radical resection
  • Small bowel malignancy

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Struck, A., Howard, T., Chiorean, E. G., Clarke, J. M., Riffenburgh, R., & Cardenes, H. R. (2009). Non-ampullary duodenal adenocarcinoma: Factors important for relapse and survival. Journal of Surgical Oncology, 100(2), 144-148. https://doi.org/10.1002/jso.21319