Non-invasive photo acoustic approach for human bone diagnosis

Ashok Kumar Thella, James Rizkalla, Ahdy Helmy, Vinay Kumar Suryadevara, Paul Salama, Maher Rizkalla

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The existing modalities of bone diagnosis including X-ray and ultrasound may cite drawback in some cases related to health issues and penetration depth, while the ultrasound modality may lack image quality. Photo acoustic approach however, provides light energy to the acoustic wave, enabling it to activate and respond according to the propagating media (which is type of bones in this case). At the same time, a differential temperature change may result in the bio heat response, resulting from the heat absorbed across the multiple materials under study. In this work, we have demonstrated the features of using photo acoustic modality in order to non-invasively diagnose the type of human bones based on their electrical, thermal, and acoustic properties that differentiate the output response of each type. COMSOL software was utilized to combine both acoustic equations and bio heat equations, in order to study both the thermal and acoustic responses through which the differential diagnosis can be obtained. In this study, we solved both the acoustic equation and bio heat equations for four types of bones, bone (cancellous), bone (cortical), bone marrow (red), and bone marrow (yellow). 1 MHz acoustic source frequency was chosen and 105 W/m2 power source was used in the simulation. The simulation tested the dynamic response of the wave over a distance of 5 cm from each side for the source. Near 2.4 cm was detected from simulation from each side of the source with a temperature change of within 0.5 K for various types of bones, citing a promising technique for a practical model to detect the type of bones via the differential temperature as well as the acoustic was response via the multiple materials associated with the human bones (skin and blood). The simulation results suggest that the PA technique may be applied to non-invasive diagnosis for the different types of bones, including cancerous bones. A practical model for detecting both the temperature change via IR sensors, and acoustic wave signals may be detected via sensitive pressure transducer, which is reserved for future realization.

Original languageEnglish (US)
Pages (from-to)394-400
Number of pages7
JournalJournal of Orthopaedics
Volume13
Issue number4
DOIs
StatePublished - Dec 1 2016

Fingerprint

Acoustics
Bone and Bones
Hot Temperature
Temperature
Bone Marrow
Pressure Transducers
Electric Power Supplies
Differential Diagnosis
Software
X-Rays
Light
Skin
Health

Keywords

  • COMSOL
  • Diagnosis
  • Ortho
  • PA
  • Photo acoustic tomography- PAT

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Thella, A. K., Rizkalla, J., Helmy, A., Suryadevara, V. K., Salama, P., & Rizkalla, M. (2016). Non-invasive photo acoustic approach for human bone diagnosis. Journal of Orthopaedics, 13(4), 394-400. https://doi.org/10.1016/j.jor.2016.07.004

Non-invasive photo acoustic approach for human bone diagnosis. / Thella, Ashok Kumar; Rizkalla, James; Helmy, Ahdy; Suryadevara, Vinay Kumar; Salama, Paul; Rizkalla, Maher.

In: Journal of Orthopaedics, Vol. 13, No. 4, 01.12.2016, p. 394-400.

Research output: Contribution to journalArticle

Thella, AK, Rizkalla, J, Helmy, A, Suryadevara, VK, Salama, P & Rizkalla, M 2016, 'Non-invasive photo acoustic approach for human bone diagnosis', Journal of Orthopaedics, vol. 13, no. 4, pp. 394-400. https://doi.org/10.1016/j.jor.2016.07.004
Thella AK, Rizkalla J, Helmy A, Suryadevara VK, Salama P, Rizkalla M. Non-invasive photo acoustic approach for human bone diagnosis. Journal of Orthopaedics. 2016 Dec 1;13(4):394-400. https://doi.org/10.1016/j.jor.2016.07.004
Thella, Ashok Kumar ; Rizkalla, James ; Helmy, Ahdy ; Suryadevara, Vinay Kumar ; Salama, Paul ; Rizkalla, Maher. / Non-invasive photo acoustic approach for human bone diagnosis. In: Journal of Orthopaedics. 2016 ; Vol. 13, No. 4. pp. 394-400.
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