Non-islet origin of pancreatic islet cell tumors

Alexander O. Vortmeyer, Steve Huang, Irina Lubensky, Zhengping Zhuang

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


The histogenesis of pancreatic islet cell tumors was investigated by morphological identification of putative precursor lesions in pancreatic tissue from patients with multiple endocrine neoplasia type 1 (MEN1), tissue microdissection, and genetic analysis. MEN1 mutation and absence of the MEN1 wild-type allele in different precursor lesions strongly suggest that pancreatic islet cell tumors are derived from the ductal/ acinar system but not from pancreatic islet tissue. Pluripotent cells within the exocrine pancreas appear capable of formation into small atypical accumulations of MEN1-deficient cells with both exocrine and endocrine phenotype. The findings suggest presence of multiple developmental aberrations in MEN1 pancreas that potentially serve as precursor material for neuroendocrine tumors.

Original languageEnglish (US)
Pages (from-to)1934-1938
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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